The correlations between angiopoietin like 8 and cardiometabolic risk factors in Saudi women with type 2 diabetes mellitus: A pilot study.

Diabetes & vascular disease research Pub Date : 2024-05-01 DOI:10.1177/14791641241259792

Walaa Mohammedsaeed, Dalal Binjawhar

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Abstract

Purpose: This study examines whether Angiopoietin Like 8 (ANGPTL8) is linked to cardiometabolic risk factors (CMRFs) in Saudi women with type 2 diabetes (T2DM).

Methods: Case-control investigation compared 150 women aged 30-60 with T2DM to 140 healthy women of the same age and gender.

Results: ANGPTL8 levels differed significantly between T2DM and non-diabetics. Fasting blood glucose (FBG), insulin resistance (IR), triglycerides (TG), high-sensitivity C-reactive protein (hs-CRP), body mass index (BMI), and atherogenic index (AIP) of plasma all correlated positively with ANGPTL8 concentrations. Insulin levels correlated negatively with ANGPTL8. Multiple linear regression models showed that elevated ANGPTL8 independently predicted higher FBG, hs-CRP, IR, TG, and AIP in T2DM patients.

Conclusion: The study found a significant association between ANGPTL8 levels and IR, hs-CRP, TG, AIP, and BMI in women with T2DM. These components are classified as CMRFs and have the potential to contribute to the development of cardiovascular disease (CVD).

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沙特女性 2 型糖尿病患者血管生成素 8 与心脏代谢风险因素之间的相关性：一项试点研究。

目的：本研究探讨了血管生成素样8（ANGPTL8）是否与患有2型糖尿病（T2DM）的沙特妇女的心脏代谢风险因素（CMRFs）有关：方法：对 150 名 30-60 岁的 T2DM 妇女和 140 名同年龄、同性别的健康妇女进行病例对照调查：结果：T2DM 和非糖尿病患者的 ANGPTL8 水平差异显著。空腹血糖（FBG）、胰岛素抵抗（IR）、甘油三酯（TG）、高敏C反应蛋白（hs-CRP）、体重指数（BMI）和血浆致动脉粥样硬化指数（AIP）均与ANGPTL8浓度呈正相关。胰岛素水平与 ANGPTL8 呈负相关。多元线性回归模型显示，ANGPTL8 升高可独立预测 T2DM 患者较高的 FBG、hs-CRP、IR、TG 和 AIP：研究发现，在 T2DM 女性患者中，ANGPTL8 水平与 IR、hs-CRP、TG、AIP 和 BMI 之间存在明显的关联。这些成分被归类为CMRF，有可能导致心血管疾病（CVD）的发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Diabetes & vascular disease research

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