Association of neutrophil/lymphocyte and platelet/lymphocyte ratios with inflammation and survival in Mexican patients on chronic hemodialysis.

Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy Pub Date : 2024-12-01 Epub Date: 2024-06-07 DOI:10.1111/1744-9987.14175

Venice Chávez Valencia, Citlalli Orizaga de la Cruz, Francisco A Lagunas-Rangel

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Abstract

Introduction: Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) are markers of systemic inflammatory status. The relationship between NLR, PLR, and mortality is controversial among hemodialysis (HD) patients.

Objective: Evaluate NLR and PLR in the prediction of mortality in chronic HD patients.

Materials and methods: We analyzed 130 patients with a follow-up for 66 months. Four groups were established according to NLR-PLR values. Kaplan-Meier curves and Cox proportional hazards analysis were used.

Results: NLR-PLR correlated positively with C-reactive protein. Cox regression analysis for overall mortality among the four groups included age (HR 1.027, 95% CI 1.003-1.053) and albumin (HR 0.25, 95% CI 0.073-0.85). For cardiovascular (CV) mortality only pulse pressure differential (PPD) was included (HR 1.033; 95% CI 1.014-1.052). Low NLRs and high PLRs were associated with CV mortality (Log Rank test, p = 0.033).

Conclusions: Low NLRs and high PLRs predict the risk of CV mortality among HD patients.

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墨西哥慢性血液透析患者的中性粒细胞/淋巴细胞和血小板/淋巴细胞比率与炎症和存活率的关系。

导言中性粒细胞-淋巴细胞比值（NLR）和血小板-淋巴细胞比值（PLR）是全身炎症状态的标志。在血液透析（HD）患者中，NLR、PLR 与死亡率之间的关系存在争议：评估 NLR 和 PLR 在预测慢性血液透析患者死亡率方面的作用：我们对随访 66 个月的 130 名患者进行了分析。根据 NLR-PLR 值分为四组。采用 Kaplan-Meier 曲线和 Cox 比例危险分析：结果：NLR-PLR与C反应蛋白呈正相关。四组总死亡率的 Cox 回归分析包括年龄（HR 1.027，95% CI 1.003-1.053）和白蛋白（HR 0.25，95% CI 0.073-0.85）。心血管（CV）死亡率仅包括脉压差（PPD）（HR 1.033；95% CI 1.014-1.052）。低 NLRs 和高 PLRs 与 CV 死亡率相关（对数秩检验，P = 0.033）：结论：低 NLRs 和高 PLRs 可预测 HD 患者的心血管疾病死亡风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy

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