Analysis of foot-originating malignant bone tumors: Epidemiology, characteristics, and survival outcomes

IF 1.9 3区医学 Q2 ORTHOPEDICS Foot and Ankle Surgery Pub Date : 2024-12-01 DOI:10.1016/j.fas.2024.05.016

Masatake Matsuoka , Tomohiro Onodera , Koji Iwasaki , Masanari Hamasaki , Taku Ebata , Yoshiaki Hosokawa , Ryuichi Fukuda , Eiji Kondo , Norimasa Iwasaki

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Abstract

Background

The study examines the characteristics and outcomes of foot-originating malignant bone tumors via Surveillance Epidemiology and End Results (SEER) database analysis.

Methods

A retrospective review of 14,695 malignant bone tumor cases from 2000 to 2019 was conducted.

Results

Of the eligible cases, 147 (2.3 %) were foot-origin tumors, typically smaller and more commonly treated with surgery than those in other locations. These tumors were more frequently treated with surgical resection, with a higher proportion undergoing amputation. In contrast, foot-origin tumors were less often managed with chemotherapy and radiation. Foot-origin tumors exhibited higher survival rates compared to non-foot-origin tumors as shown in univariate analysis, although multivariate analysis did not reflect significant differences.

Conclusion

Foot-originating malignant bone tumors tend to be smaller and are frequently surgically treated, correlating with favorable survival outcomes. These findings point to early detection as a potential factor in the improved survival rates, not necessarily the tumor's origin.

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足部恶性骨肿瘤分析：流行病学、特征和生存结果。

背景：该研究通过对监测流行病学和最终结果（SEER）数据库的分析，研究足部恶性骨肿瘤的特征和结局：该研究通过监测流行病学和最终结果（SEER）数据库分析，研究了足部恶性骨肿瘤的特征和结局：方法：对2000年至2019年的14695例恶性骨肿瘤病例进行回顾性研究：在符合条件的病例中，147 例（2.3%）为足部肿瘤，与其他部位的肿瘤相比，足部肿瘤通常较小，更常采用手术治疗。这些肿瘤更常接受手术切除治疗，接受截肢治疗的比例更高。相比之下，足源性肿瘤较少接受化疗和放疗。单变量分析显示，足源性肿瘤的存活率高于非足源性肿瘤，但多变量分析并未反映出显著差异：结论：源于足部的恶性骨肿瘤往往较小，而且经常接受手术治疗，因此生存率较高。这些研究结果表明，早期发现是提高生存率的潜在因素，而不一定是肿瘤的来源。

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来源期刊

Foot and Ankle Surgery ORTHOPEDICS-

CiteScore

4.60

自引率

16.00%

发文量

202

期刊介绍： Foot and Ankle Surgery is essential reading for everyone interested in the foot and ankle and its disorders. The approach is broad and includes all aspects of the subject from basic science to clinical management. Problems of both children and adults are included, as is trauma and chronic disease. Foot and Ankle Surgery is the official journal of European Foot and Ankle Society. The aims of this journal are to promote the art and science of ankle and foot surgery, to publish peer-reviewed research articles, to provide regular reviews by acknowledged experts on common problems, and to provide a forum for discussion with letters to the Editors. Reviews of books are also published. Papers are invited for possible publication in Foot and Ankle Surgery on the understanding that the material has not been published elsewhere or accepted for publication in another journal and does not infringe prior copyright.