Chen Chen, Lingling Liu, Siyao Ye, Jialin Li, Li Wu, Junsen Li, Hao Jia, Yuhua Long
{"title":"New steroids from mangrove-associated fungus Trichoderma asperellum SCNU-F0048","authors":"Chen Chen, Lingling Liu, Siyao Ye, Jialin Li, Li Wu, Junsen Li, Hao Jia, Yuhua Long","doi":"10.1016/j.steroids.2024.109449","DOIUrl":null,"url":null,"abstract":"<div><p>Chemical investigation of the fungus <em>Trichoderma asperellum</em> SCNU-F0048 led to the discovery of two new steroids, ergosta-4,6,8 (14),22-tetraen-3-(3′-methyl-4′-hydroxyl-<em>γ</em>-butenolide) (<strong>1</strong>) and camphosterol B (<strong>2</strong>), as well as two known compounds, i.e. stigmasta-4,6,8(14),22-tetraen-3-one (<strong>3</strong>) and 4-hydroxy-17- methylincisterol (<strong>4</strong>). Their structures were elucidated by extensive nuclear mangnetic resonance, spectrum analysis and single crystal X-ray diffraction analysis. Bioassay disclosed that compound <strong>1</strong> showed strong cytotoxicity to a panel of tumor cell lines. Moreover, compounds <strong>1</strong> and <strong>2</strong> showed excellent antifungal activity against <em>Penicillium italicum</em> with IC<sub>50</sub> values of 0.016 and 0.022 μM, respectively.</p></div>","PeriodicalId":21997,"journal":{"name":"Steroids","volume":"208 ","pages":"Article 109449"},"PeriodicalIF":2.1000,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Steroids","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0039128X24000874","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Chemical investigation of the fungus Trichoderma asperellum SCNU-F0048 led to the discovery of two new steroids, ergosta-4,6,8 (14),22-tetraen-3-(3′-methyl-4′-hydroxyl-γ-butenolide) (1) and camphosterol B (2), as well as two known compounds, i.e. stigmasta-4,6,8(14),22-tetraen-3-one (3) and 4-hydroxy-17- methylincisterol (4). Their structures were elucidated by extensive nuclear mangnetic resonance, spectrum analysis and single crystal X-ray diffraction analysis. Bioassay disclosed that compound 1 showed strong cytotoxicity to a panel of tumor cell lines. Moreover, compounds 1 and 2 showed excellent antifungal activity against Penicillium italicum with IC50 values of 0.016 and 0.022 μM, respectively.
期刊介绍：
STEROIDS is an international research journal devoted to studies on all chemical and biological aspects of steroidal moieties. The journal focuses on both experimental and theoretical studies on the biology, chemistry, biosynthesis, metabolism, molecular biology, physiology and pharmacology of steroids and other molecules that target or regulate steroid receptors. Manuscripts presenting clinical research related to steroids, steroid drug development, comparative endocrinology of steroid hormones, investigations on the mechanism of steroid action and steroid chemistry are all appropriate for submission for peer review. STEROIDS publishes both original research and timely reviews. For details concerning the preparation of manuscripts see Instructions to Authors, which is published in each issue of the journal.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
