Exploring the role of gut microbes in spondyloarthritis: Implications for pathogenesis and therapeutic strategies

IF 4.5 2区 医学 Q1 RHEUMATOLOGY Best Practice & Research in Clinical Rheumatology Pub Date : 2024-05-01 DOI:10.1016/j.berh.2024.101961
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Abstract

The gut microbiota plays a pivotal role in regulating host immunity, and dysregulation of this interaction is implicated in autoimmune and inflammatory diseases, including spondyloarthritis (SpA). This review explores microbial dysbiosis and altered metabolic function observed in various forms of SpA, such as ankylosing spondylitis (AS), psoriatic arthritis (PsA), acute anterior uveitis (AAU), and SpA-associated gut inflammation. Studies on animal models and clinical samples highlight the association between gut microbial dysbiosis, metabolic perturbations and immune dysregulation in SpA pathogenesis. These studies have received impetus through next-generation sequencing methods, which have enabled the characterization of gut microbial composition and function, and host gene expression. Microbial/metabolomic studies have revealed potential biomarkers and therapeutic targets, such as short-chain fatty acids, and tryptophan metabolites, offering insights into disease mechanisms and treatment approaches. Further studies on microbial function and its modulation of the immune response have uncovered molecular mechanisms underlying various SpA. Understanding the complex interplay between microbial community structure and function holds promise for improved diagnosis and management of SpA and other autoimmune disorders.

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探索肠道微生物在脊柱关节炎中的作用:对发病机制和治疗策略的影响。
肠道微生物群在调节宿主免疫力方面起着关键作用,这种相互作用的失调与自身免疫性和炎症性疾病(包括脊柱关节炎)有关。本综述探讨了在强直性脊柱炎(AS)、银屑病关节炎(PsA)、急性前葡萄膜炎(AAU)等各种形式的脊柱关节炎中观察到的微生物菌群失调和代谢功能改变,以及与脊柱关节炎相关的肠道炎症。对动物模型和临床样本的研究强调了肠道微生物菌群失调、代谢紊乱和免疫失调在 SpA 发病机制中的关联。下一代测序方法对这些研究起到了推动作用,从而能够确定肠道微生物组成和功能以及宿主基因表达的特征。微生物/代谢组学研究揭示了潜在的生物标记物和治疗靶点,如短链脂肪酸和色氨酸代谢物,为疾病机制和治疗方法提供了见解。有关微生物功能及其对免疫反应调节的进一步研究揭示了各种 SpA 的分子机制。了解微生物群落结构和功能之间复杂的相互作用,有望改善 SpA 和其他自身免疫性疾病的诊断和管理。
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来源期刊
CiteScore
9.40
自引率
0.00%
发文量
43
审稿时长
27 days
期刊介绍: Evidence-based updates of best clinical practice across the spectrum of musculoskeletal conditions. Best Practice & Research: Clinical Rheumatology keeps the clinician or trainee informed of the latest developments and current recommended practice in the rapidly advancing fields of musculoskeletal conditions and science. The series provides a continuous update of current clinical practice. It is a topical serial publication that covers the spectrum of musculoskeletal conditions in a 4-year cycle. Each topic-based issue contains around 200 pages of practical, evidence-based review articles, which integrate the results from the latest original research with current clinical practice and thinking to provide a continuous update. Each issue follows a problem-orientated approach that focuses on the key questions to be addressed, clearly defining what is known and not known. The review articles seek to address the clinical issues of diagnosis, treatment and patient management. Management is described in practical terms so that it can be applied to the individual patient. The serial is aimed at the physician in both practice and training.
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