The Impact of Weight-bearing Exercise, Non-Weight-bearing Exercise, and Cardiovascular Stress on Biochemical Markers of Cartilage Turnover in Patients With Mild to Moderate Knee Osteoarthritis: A Sequential, Cross-Over, Clinical Study.

IF 2.7 4区医学 Q1 ORTHOPEDICS CARTILAGE Pub Date : 2024-06-09 DOI:10.1177/19476035241258170

Jonathan J Bjerre-Bastos, Casper Sejersen, Henning Bay Nielsen, Mikael Boesen, Niels H Secher, Gregorio Distajo, Vincent Flood, Yves Henrotin, Melanie Uebelhoer, Peter Krustrup, Carl-Christian Kitchen, Christian S Thudium, Jeppe R Andersen, Asger R Bihlet

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Abstract

Objective: To investigate how running, cycling, and sedentary cardiovascular stress impact biomarkers of cartilage turnover acutely in subjects with knee osteoarthritis (OA).

Design: This was a sequential, cross-over, clinical study. Forty subjects with primary knee OA underwent moderate-to-high-intensity cycling, running, and adrenaline infusion on separate days. Blood was sampled before, during, and at 6-time points after intervention. On a control day, similar samples were taken. Biomarkers of type II collagen degradation (C2M, T2CM, Coll2-1, Coll2-1NO2), formation (PRO-C2), and aggrecan degradation (ARGS) were measured.

Results: Mean age was 60.4 years, 40% were male, 45% had cumulated Kellgren-Lawrence (KL)-grade (Right + Left knee) of 2 to 3 and 55% had 4 to 6. Analyzing overall changes, area under the curve was significantly lower compared with resting values for ARGS and C2M after cycling and for ARGS after running. Considering individual time points, peak changes in biomarker levels showed reduction in C2M shortly following cycling (T_20min = -12.3%, 95% confidence interval [CI]: -19.3% to -5.2%). PRO-C2 increased during cycling (T_10min = 14.0%, 95% CI = 4.1% to 23.8%) and running (T_20min = 16.5%, 95% CI = 4.3% to 28.6%). T2CM decreased after cycling (T_50min = -19.9%, 95% CI = -29.2% to -10.6%), running (T_50min = -22.8%, 95% CI = -32.1% to -13.5%), and infusion of adrenaline (peak, T_50min = -9.8%, 95% CI = -20.0% to 0.4%). A latent increase was seen in Coll2-1 240 minutes after running (T_260min = 21.7%, 95% CI = -1.6% to 45.1%).

Conclusion: Exercise had an impact on cartilage markers, but it did not suggest any detrimental effect on cartilage. Changes following adrenaline infusion suggest a sympathomimetic influence on the serological composition of biomarkers.

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负重运动、非负重运动和心血管压力对轻度至中度膝骨关节炎患者软骨周转生化指标的影响：一项连续、交叉的临床研究。

目的：研究跑步、骑自行车和久坐对心血管压力的影响：研究跑步、骑自行车和久坐对心血管压力的影响：这是一项连续、交叉的临床研究。40 名患有原发性膝关节 OA 的受试者分别在不同的日子里进行了中高强度的骑车、跑步和肾上腺素注射。在干预前、干预期间和干预后的 6 个时间点采集了血液样本。在对照日也采集了类似的样本。测量了 II 型胶原降解（C2M、T2CM、Coll2-1、Coll2-1NO2）、形成（PRO-C2）和凝集素降解（ARGS）的生物标志物：平均年龄为 60.4 岁，40% 为男性，45% 的患者累积 Kellgren-Lawrence (KL) 等级（右膝关节 + 左膝关节）为 2 至 3 级，55% 为 4 至 6 级。分析整体变化，骑车后 ARGS 和 C2M 的曲线下面积明显低于静息值，跑步后 ARGS 的曲线下面积也明显低于静息值。就单个时间点而言，生物标志物水平的峰值变化显示，骑车后不久，C2M 水平下降（T20min = -12.3%，95% 置信区间[CI]：-19.3% 至 -5.2%）。PRO-C2 在骑车（T10min = 14.0%，95% 置信区间 = 4.1% 至 23.8%）和跑步（T20min = 16.5%，95% 置信区间 = 4.3% 至 28.6%）期间增加。T2CM 在骑自行车（T50min = -19.9%，95% CI = -29.2%至 -10.6%）、跑步（T50min = -22.8%，95% CI = -32.1%至 -13.5%）和注射肾上腺素（峰值，T50min = -9.8%，95% CI = -20.0%至 0.4%）后下降。跑步后240分钟，Coll2-1出现潜伏增加（T260min = 21.7%，95% CI = -1.6% 至 45.1%）：结论：运动对软骨标志物有影响，但并不表明运动对软骨有任何不利影响。肾上腺素注射后的变化表明，拟交感神经对生物标志物的血清学组成有影响。

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来源期刊

CARTILAGE ORTHOPEDICS-

CiteScore

6.90

自引率

7.10%

发文量

期刊介绍： CARTILAGE publishes articles related to the musculoskeletal system with particular attention to cartilage repair, development, function, degeneration, transplantation, and rehabilitation. The journal is a forum for the exchange of ideas for the many types of researchers and clinicians involved in cartilage biology and repair. A primary objective of CARTILAGE is to foster the cross-fertilization of the findings between clinical and basic sciences throughout the various disciplines involved in cartilage repair. The journal publishes full length original manuscripts on all types of cartilage including articular, nasal, auricular, tracheal/bronchial, and intervertebral disc fibrocartilage. Manuscripts on clinical and laboratory research are welcome. Review articles, editorials, and letters are also encouraged. The ICRS envisages CARTILAGE as a forum for the exchange of knowledge among clinicians, scientists, patients, and researchers. The International Cartilage Repair Society (ICRS) is dedicated to promotion, encouragement, and distribution of fundamental and applied research of cartilage in order to permit a better knowledge of function and dysfunction of articular cartilage and its repair.