Diuretics use in the management of hypertension

IF 1.2 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Hipertension y Riesgo Vascular Pub Date : 2024-07-01 DOI:10.1016/j.hipert.2024.03.004
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Abstract

Diuretics have been used for decades in the treatment of hypertension. Its efficacy has been demonstrated in numerous clinical trials. It is well known that the reduction in cardiovascular risk is a consequence of the reduction in blood pressure levels regardless of the drug used, but thiazide diuretics continue to be first-line drugs, especially in low doses and combined with other drugs. The debate on the advantages of using chlorthalidone or hydrochlorothiazide continues, however hydrochlorothiazide is drug most used and for which there is greater availability. The association with potassium-sparing diuretics increases the effectiveness and reduces the adverse reactions of thiazides. A new group of drugs, close to potassium-sparing diuretics, that antagonise aldosterone synthase are showing promising results as antihypertensives. There are no significant differences between men and women regarding the antihypertensive effect of thiazide diuretics.

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在高血压治疗中使用利尿剂。
几十年来,利尿剂一直被用于治疗高血压。许多临床试验都证明了其疗效。众所周知,无论使用哪种药物,心血管风险的降低都是血压水平降低的结果,但噻嗪类利尿剂仍是一线药物,尤其是小剂量和与其他药物联合使用时。关于使用氯塞酮或氢氯噻嗪的优势的争论仍在继续,但氢氯噻嗪是使用最多的药物,也更容易获得。与保钾利尿剂合用可提高噻嗪类药物的疗效,并减少其不良反应。与保钾利尿剂相近的一类新药是拮抗醛固酮合成酶的药物,作为降压药使用效果很好。在噻嗪类利尿剂的降压效果方面,男女之间没有明显差异。
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来源期刊
Hipertension y Riesgo Vascular
Hipertension y Riesgo Vascular Medicine-Internal Medicine
CiteScore
1.70
自引率
16.70%
发文量
38
审稿时长
39 days
期刊介绍: La mejor publicación para mantenerse al día en los avances de la lucha contra esta patología. Incluye artículos de Investigación, Originales, Revisiones, Casos clínicos, Aplicación práctica y Resúmenes comentados a la bibliografía internacional. Además, es la Publicación Oficial de la Sociedad española de Hipertensión-Liga Española para la Lucha contra la Hipertensión Arterial.
期刊最新文献
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