Investigation of PD-1 gene variants in patients with endometrial cancer: A case-control study.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-06-10 DOI:10.4274/tjod.galenos.2024.71508

Mohammad Javad Fattahi, Mozhdeh Momtahan, Maryam Poostkar, Zahra Shiravani, Nasrollah Erfani, Mohammad Reza Haghshenas, Masoumeh Hashemi, Abbas Ghaderi, Ali Kashkooe

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Abstract

Objective: To assess the possible association of two single-nucleotide polymorphisms (SNPs), PD-1.3 (+7146G/A) and PD-1.5 (+7785C/T), with endometrial cancer (EC) susceptibility. In addition, the correlations between these SNPs and available clinicopathologic characteristics of patients with EC were investigated.

Materials and methods: In this case-control study, 147 women with pathologically confirmed EC and 258 age- and ethnically matched healthy women were enrolled between June 2019 and May 2022. Genomic DNA was extracted, and genotyping of PD-1.3 (+7146G/A) and PD-1.5 (+7785C/T) SNPs was performed. Haplotype analysis was also performed. Pearson's chi-square test with Yates correction was used to evaluate differences in allele and genotype distributions. The 95% confidence interval and odds ratio were determined using an unconditional logistic regression model.

Results: There were no remarkable differences in the allele and genotype distributions of PD-1.3 (rs11568821) and PD-1.5 (rs2227981) between healthy controls and EC patients. However, there was a remarkable difference in the AC haplotype between the control and EC groups. No association was found between the investigated SNPs and the clinicopathologic features of EC.

Conclusion: Our results indicated that the aforementioned SNPs were not related to the risk of EC in the southern Iranian population.

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子宫内膜癌患者的 PD-1 基因变异调查：病例对照研究

目的评估PD-1.3（+7146G/A）和PD-1.5（+7785C/T）这两个单核苷酸多态性（SNPs）与子宫内膜癌（EC）易感性之间可能存在的关联。此外，研究还探讨了这些 SNP 与子宫内膜癌患者现有临床病理特征之间的相关性：在这项病例对照研究中，在2019年6月至2022年5月期间，共招募了147名经病理学确诊的EC女性和258名年龄和种族匹配的健康女性。提取了基因组 DNA，并对 PD-1.3 (+7146G/A) 和 PD-1.5 (+7785C/T) SNPs 进行了基因分型。同时还进行了单倍型分析。评估等位基因和基因型分布差异时，采用了带有耶茨校正的皮尔逊卡方检验。使用无条件逻辑回归模型确定了 95% 的置信区间和几率：PD-1.3（rs11568821）和PD-1.5（rs2227981）的等位基因和基因型分布在健康对照组和欧共体患者之间没有明显差异。然而，对照组和心血管疾病组之间的 AC 单倍型存在显著差异。结论：我们的研究结果表明，上述SNPs与EC的临床病理特征之间没有关联：我们的研究结果表明，在伊朗南部人群中，上述 SNP 与心肌梗死风险无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.