Biophysical perspectives to understanding cancer-associated fibroblasts.

IF 6.6 3区 医学 Q1 ENGINEERING, BIOMEDICAL APL Bioengineering Pub Date : 2024-06-06 eCollection Date: 2024-06-01 DOI:10.1063/5.0199024
Somayadineshraj Devarasou, Minwoo Kang, Jennifer H Shin
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Abstract

The understanding of cancer has evolved significantly, with the tumor microenvironment (TME) now recognized as a critical factor influencing the onset and progression of the disease. This broader perspective challenges the traditional view that cancer is primarily caused by mutations, instead emphasizing the dynamic interaction between different cell types and physicochemical factors within the TME. Among these factors, cancer-associated fibroblasts (CAFs) command attention for their profound influence on tumor behavior and patient prognoses. Despite their recognized importance, the biophysical and mechanical interactions of CAFs within the TME remain elusive. This review examines the distinctive physical characteristics of CAFs, their morphological attributes, and mechanical interactions within the TME. We discuss the impact of mechanotransduction on CAF function and highlight how these cells communicate mechanically with neighboring cancer cells, thereby shaping the path of tumor development and progression. By concentrating on the biomechanical regulation of CAFs, this review aims to deepen our understanding of their role in the TME and to illuminate new biomechanical-based therapeutic strategies.

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从生物物理角度了解癌症相关成纤维细胞。
人们对癌症的认识有了很大的发展,肿瘤微环境(TME)现已被认为是影响疾病发生和发展的关键因素。这一更广阔的视角挑战了癌症主要由突变引起的传统观点,转而强调肿瘤微环境中不同细胞类型和理化因素之间的动态相互作用。在这些因素中,癌症相关成纤维细胞(CAFs)因其对肿瘤行为和患者预后的深远影响而备受关注。尽管CAFs的重要性已得到公认,但其在TME内的生物物理和机械相互作用仍然难以捉摸。本综述探讨了 CAFs 独特的物理特征、形态属性以及在 TME 内的机械相互作用。我们讨论了机械传导对 CAF 功能的影响,并强调了这些细胞如何与邻近癌细胞进行机械交流,从而影响肿瘤的发展和进程。通过集中探讨 CAF 的生物力学调控,本综述旨在加深我们对 CAF 在 TME 中作用的理解,并阐明基于生物力学的新治疗策略。
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来源期刊
APL Bioengineering
APL Bioengineering ENGINEERING, BIOMEDICAL-
CiteScore
9.30
自引率
6.70%
发文量
39
审稿时长
19 weeks
期刊介绍: APL Bioengineering is devoted to research at the intersection of biology, physics, and engineering. The journal publishes high-impact manuscripts specific to the understanding and advancement of physics and engineering of biological systems. APL Bioengineering is the new home for the bioengineering and biomedical research communities. APL Bioengineering publishes original research articles, reviews, and perspectives. Topical coverage includes: -Biofabrication and Bioprinting -Biomedical Materials, Sensors, and Imaging -Engineered Living Systems -Cell and Tissue Engineering -Regenerative Medicine -Molecular, Cell, and Tissue Biomechanics -Systems Biology and Computational Biology
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