Natalia Ratusznik, Sofie Marie Edslev, Marc Stegger, Bo Söderquist
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引用次数: 0
Abstract
Patients with atopic dermatitis (AD) are more likely than healthy individuals to harbour Staphylococcus aureus on their skin. Superantigens (SAgs) produced by specific S. aureus strains may contribute to AD-associated skin inflammation. The present study compared the prevalence and types of SAg-encoding genes between S. aureus isolated from patients with AD and from controls, and within the AD group between isolates from different sampling sites (lesional skin, non-lesional skin, and nares). This retrospective case-control study extracted data from 2 previous studies that examined S. aureus using whole-genome sequencing. The 138 S. aureus isolates obtained from 71 AD patients contained 349 SAg-encoding genes; 22 (6.3%) were found in isolates from nares (0.4 ± 0.6 genes per isolate), 99 (28.4%) in isolates from non-lesional skin (3.7 ± 3.9), and 228 (65.3%) in isolates from lesional skin (4.2 ± 4.5). S. aureus (n = 101) from the control group contained 594 SAg-encoding genes (5.9 ± 4.2). Of the S. aureus isolated from lesional AD skin, 69% carried at least 1 gene encoding SAg compared with 33% of AD nasal isolates. SAg could be a factor in the pathogenesis of a subset of AD patients.
与健康人相比,特应性皮炎(AD)患者的皮肤上更容易携带金黄色葡萄球菌。由特定金黄色葡萄球菌菌株产生的超级抗原(SAgs)可能会导致与特应性皮炎相关的皮肤炎症。本研究比较了从 AD 患者和对照组中分离出的金黄色葡萄球菌以及 AD 组中从不同取样部位(病变皮肤、非病变皮肤和鼻腔)分离出的金黄色葡萄球菌的 SAg 编码基因的流行率和类型。这项回顾性病例对照研究从之前两项使用全基因组测序法检测金黄色葡萄球菌的研究中提取了数据。从71名AD患者中分离出的138株金黄色葡萄球菌含有349个SAg编码基因;其中22株(6.3%)来自鼻腔(每株0.4±0.6个基因),99株(28.4%)来自非皮损皮肤(3.7±3.9个基因),228株(65.3%)来自皮损皮肤(4.2±4.5个基因)。对照组的金黄色葡萄球菌(n = 101)含有 594 个 SAg 编码基因(5.9 ± 4.2)。从AD病变皮肤分离出的金黄色葡萄球菌中,69%至少携带1个编码SAg的基因,而AD鼻腔分离物中这一比例为33%。SAg可能是导致部分AD患者发病的一个因素。
期刊介绍:
Acta Dermato-Venereologica publishes high-quality manuscripts in English in the field of Dermatology and Venereology, dealing with new observations on basic dermatological and venereological research, as well as clinical investigations. Each volume also features a number of Review articles in special areas, as well as short Letters to the Editor to stimulate debate and to disseminate important clinical observations. Acta Dermato-Venereologica has rapid publication times and is amply illustrated with a large number of colour photographs.