Modeling Parkinson's Disease in Primates.

IF 7.8 2区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Cold Spring Harbor perspectives in medicine Pub Date : 2024-07-15 DOI:10.1101/cshperspect.a041612
Erwan Bezard, Margaux Teil, Marie-Laure Arotcarena, Gregory Porras, Qin Li, Benjamin Dehay
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Abstract

Decades of research have identified the pathological and pathophysiological hallmarks of Parkinson's disease (PD): profound deficit in brain dopamine and other monoamines, pathological α-synuclein aggregation, synaptic and neuronal network dysfunction, aberrant proteostasis, altered energy homeostasis, inflammation, and neuronal cell death. The purpose of this contribution is to present the phenocopy aspect, pathogenic, and etiologic nonhuman primate (NHP) models of PD to readers with limited prior knowledge of PD so that they are ready to start working on PD. How NHPs, the closest species to man on which we can model diseases, contribute to the knowledge progress and how these models represent an invaluable translational step in therapeutic development are highlighted.

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灵长类动物的帕金森病模型
数十年的研究已经确定了帕金森病(PD)的病理和病理生理学特征:大脑多巴胺和其他单胺类物质的严重缺乏、病理性α-突触核蛋白聚集、突触和神经元网络功能障碍、异常蛋白稳态、能量稳态改变、炎症和神经细胞死亡。本文旨在向对帕金森病了解有限的读者介绍帕金森病的表型方面、致病性和病因学非人灵长类动物(NHP)模型,以便他们做好准备开始研究帕金森病。非人灵长类动物是最接近人类的物种,我们可以在它们身上建立疾病模型,重点介绍非人灵长类动物如何促进知识进步,以及这些模型如何代表治疗开发中宝贵的转化步骤。
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来源期刊
Cold Spring Harbor perspectives in medicine
Cold Spring Harbor perspectives in medicine MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
14.30
自引率
1.90%
发文量
44
审稿时长
4-8 weeks
期刊介绍: Cold Spring Harbor Perspectives in Medicine is a monthly online publication comprising reviews on different aspects of a variety of diseases, covering everything from the molecular and cellular bases of disease to translational medicine and new therapeutic strategies. Cold Spring Harbor Perspectives in Medicine is thus unmatched in its depth of coverage and represents an essential source where readers can find informed surveys and critical discussion of advances in molecular medicine.
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