Long-term efficacy of washed microbiota transplantation in overweight patients

IF 4.4 3区医学 Q1 MEDICINE, GENERAL & INTERNAL European Journal of Clinical Investigation Pub Date : 2024-06-10 DOI:10.1111/eci.14260

Dejiang Lin, Dongxia Hu, Youlin Song, Xingxiang He, Lei Wu

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Abstract

Background

Faecal microbiota transplantation holds promise in mitigating fat accumulation and improving obesity. This study aimed to evaluate the long-term efficacy of washed microbiota transplantation (WMT) among overweight patients.

Methods

The clinical data pertaining to the treatment of patients with WMT were collected retrospectively. Compared alterations in body mass index (BMI), blood glucose, blood lipids and blood pressure prior to and following WMT treatment. Comprehensive efficacy evaluation and atherosclerosis cardiovascular disease (ASCVD) grading evaluation were carried out, with an analysis of gut microbiota composition before and after WMT.

Results

A total of 186 patients were included (80 overweight, 106 normal weight). WMT not only had the effect of improving overweight patients to the normal weight patients (p < .001), but also could significantly reduce BMI in the long term by restoring gut microbiota homeostasis (p < .001). In addition, the BMI improvement value of multi course was more significant than that of single course or double course. WMT had a significant ASCVD downgrade effect on the high-risk and medium-risk groups outside 1 year, while it did not increase the risk of upgrading ASCVD for low-risk group.

Conclusions

WMT could significantly reduce the BMI of overweight patients and still had an improvement effect in the long term.

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洗胃微生物群移植对超重患者的长期疗效。

背景：粪便微生物群移植有望减轻脂肪堆积和改善肥胖。本研究旨在评估粪便微生物群移植（WMT）对超重患者的长期疗效：方法：研究人员回顾性地收集了与粪便微生物群移植治疗患者相关的临床数据。比较WMT治疗前后体重指数（BMI）、血糖、血脂和血压的变化。进行了综合疗效评估和动脉粥样硬化性心血管疾病（ASCVD）分级评估，并对WMT治疗前后的肠道微生物群组成进行了分析：共纳入 186 名患者（80 名超重，106 名体重正常）。结果：共纳入 186 名患者（80 名超重患者和 106 名正常体重患者）：WMT能明显降低超重患者的体重指数，而且长期来看仍有改善效果。

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来源期刊

European Journal of Clinical Investigation 医学-医学：内科

CiteScore

9.50

自引率

3.60%

发文量

192

审稿时长

1 months

期刊介绍： EJCI considers any original contribution from the most sophisticated basic molecular sciences to applied clinical and translational research and evidence-based medicine across a broad range of subspecialties. The EJCI publishes reports of high-quality research that pertain to the genetic, molecular, cellular, or physiological basis of human biology and disease, as well as research that addresses prevalence, diagnosis, course, treatment, and prevention of disease. We are primarily interested in studies directly pertinent to humans, but submission of robust in vitro and animal work is also encouraged. Interdisciplinary work and research using innovative methods and combinations of laboratory, clinical, and epidemiological methodologies and techniques is of great interest to the journal. Several categories of manuscripts (for detailed description see below) are considered: editorials, original articles (also including randomized clinical trials, systematic reviews and meta-analyses), reviews (narrative reviews), opinion articles (including debates, perspectives and commentaries); and letters to the Editor.