Using an Innovative Method for Self-Collection of Capillary Blood for HIV and Syphilis Testing Among Men Who Have Sex With Men Who Use Pre-exposure Prophylaxis in the Netherlands; Limburg4zero.

IF 2.4 4区 医学 Q3 INFECTIOUS DISEASES Sexually transmitted diseases Pub Date : 2024-08-01 Epub Date: 2024-03-14 DOI:10.1097/OLQ.0000000000001969
Cornelia J D Goense, Ymke J Evers, Inge H M van Loo, Rosalie J M Heuts, Christian J P A Hoebe, Chase A Cannon, Nicole H T M Dukers-Muijrers
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Abstract

Background: Home-based sampling could create accessible testing opportunities for men who have sex with men (MSM) who use pre-exposure prophylaxis (PrEP). Blood collection is required for the most reliable laboratory results for HIV and syphilis testing. An innovative blood collection method (Tasso+) creates a vacuum and semi-automatically collects larger volumes of blood from the upper arm. This study aimed to assess acceptability and feasibility of this device among PrEP-using MSM and the performance of blood collection.

Methods: Between August 2022 and January 2023, 47 MSM were recruited during their routine PrEP consultations at a Dutch Centre for Sexual Health. Participants tested the method directly after consultation, and an online questionnaire determined acceptability and feasibility. Blood and residual serum volumes were measured after sampling and after HIV and syphilis testing.

Results: Of the participants, 87% had a positive attitude toward use of the device, and 77% would use it again for self-sampling at home. Participants rated the use of the blood collection device as easy (96%). On average, 536 μL whole blood (244 μL serum) was collected. All samples were tested for HIV and syphilis, and most samples had sufficient blood for routine HIV (91%) and syphilis testing (89%). Most samples (85%) had 220 μL residual blood, sufficient for further testing (e.g., confirmation).

Conclusions: Blood self-sampling with a method that creates a vacuum from the upper arm is highly acceptable by users and performs well in blood collection for multiple tests. This method has promising potential for use in home-based sexual health care for PrEP-using MSM.

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在荷兰使用 PrEP 的男男性行为者中使用创新方法自我采集毛细血管血液进行艾滋病毒和梅毒检测;Limburg4zero.
背景:家庭采样可为使用暴露前预防疗法(PrEP)的男男性行为者(MSM)提供方便的检测机会。要想获得最可靠的艾滋病毒和梅毒实验室检测结果,就必须进行采血。一种创新的采血方法(Tasso+)能产生真空,半自动地从上臂采集更大量的血液。本研究旨在评估使用 PrEP 的 MSM 对该设备的接受度和可行性以及采血效果:方法:2022 年 8 月至 2023 年 1 月期间,在荷兰性健康中心的常规 PrEP 咨询中招募了 47 名 MSM。参与者在咨询后直接测试该方法,并通过在线问卷调查确定接受度和可行性。在采样后以及艾滋病毒和梅毒检测后测量了血液和残余血清量:结果:87%的参与者对该装置的使用持积极态度,77%的参与者会再次使用该装置在家中进行自我采样。参与者认为采血器的使用很简单(96%)。平均采集了 536 μl 全血(244 μl 血清)。所有样本都进行了艾滋病毒和梅毒检测,大多数样本都有足够的血液进行常规艾滋病毒(91%)和梅毒(89%)检测。大多数样本(85%)都有 220 μl 的残留血液,足以进行进一步检测(如确认):使用从上臂抽取真空的方法进行血液自我采样,用户的接受度很高,而且在为多项检测采集血液方面表现良好。这种方法有望用于对使用 PrEP 的 MSM 进行家庭性保健。
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来源期刊
Sexually transmitted diseases
Sexually transmitted diseases 医学-传染病学
CiteScore
4.00
自引率
16.10%
发文量
289
审稿时长
3-8 weeks
期刊介绍: ​Sexually Transmitted Diseases, the official journal of the American Sexually Transmitted Diseases Association​, publishes peer-reviewed, original articles on clinical, laboratory, immunologic, epidemiologic, behavioral, public health, and historical topics pertaining to sexually transmitted diseases and related fields. Reports from the CDC and NIH provide up-to-the-minute information. A highly respected editorial board is composed of prominent scientists who are leaders in this rapidly changing field. Included in each issue are studies and developments from around the world.
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