Next-level precision medicine: why the theragnostic approach is the future.

Aniello Iacomino, Marco Rapa, Gianluca Gatta, Graziella DI Grezia, Vincenzo Cuccurullo
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Abstract

Theragnostics represents one of the most innovative fields of precision medicine with a huge potential in the field of oncology in the next years. The use of a pair of selective radiopharmaceuticals for cellular receptors, used for diagnostic and therapeutic purposes (PRRT), finds applications in the Neuroendocrine tumors and metastatic Castration-Resistant prostate cancer (mCRPC) thanks, respectively, to somatostatin receptor agonists and PSMA-based peptides. Further evolutions of theragnostics will be possible to the radioimmunoconjugates used both in the diagnostic (Immuno-PET) and in the therapeutic fields (radioimmunotherapy). It is evident that in the "omics-era," theragnostics could become a necessary method, not only in order to improve our knowledge of tumor biology, but also, to find more and more targeted therapies in a multidisciplinary context and in a tailor-based approach.

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下一阶段的精准医疗:为什么治疗诊断方法是未来的趋势?
热诊断技术是精准医疗最具创新性的领域之一,在未来几年的肿瘤学领域具有巨大潜力。体生长抑素受体激动剂和基于 PSMA 的多肽可分别用于神经内分泌肿瘤和转移性阉割抗性前列腺癌(mCRPC)的诊断和治疗(PRRT)。放射免疫共轭物在诊断(免疫 PET)和治疗(放射免疫疗法)领域的应用,将进一步推动热诊断技术的发展。显而易见,在 "全息时代",热释光技术将成为一种必要的方法,不仅能提高我们对肿瘤生物学的认识,还能在多学科背景下以量身定制的方式找到越来越多的靶向疗法。
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来源期刊
the Quarterly Journal of Nuclear Medicine and Molecular Imaging
the Quarterly Journal of Nuclear Medicine and Molecular Imaging Medicine-Radiology, Nuclear Medicine and Imaging
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期刊介绍: The Quarterly Journal of Nuclear Medicine and Molecular Imaging publishes scientific papers on clinical and experimental topics of nuclear medicine. Manuscripts may be submitted in the form of editorials, original articles, review articles and special articles. The journal aims to provide its readers with papers of the highest quality and impact through a process of careful peer review and editorial work.
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