Relationship between muscle and subcutaneous adipose tissue size and density and proximal femur bone in elderly women with hip fracture.

IF 3.4 3区 医学 Q2 GERIATRICS & GERONTOLOGY Aging Clinical and Experimental Research Pub Date : 2024-06-11 DOI:10.1007/s40520-024-02782-y
Yangtong Li, Chenjun Liu, Jing Lu, Hui Sun, Yuehua Li
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Abstract

Background: Both osteoporosis and sarcopenia are associated with aging, increasing the likelihood of falls in older adults and consequently raising the risk of hip fractures (HF).

Aims: To explore the relationship between the size and density of muscle and subcutaneous adipose tissue (SAT) and the bone mineral density (BMD) of the proximal femur in elderly women with HF.

Methods: Quantitative computed tomography (QCT) was conducted on the hips of 661 female participants who experienced low-energy acute HFs to measure both areal BMD (aBMD) and volume BMD (vBMD). Measurements were taken for the cross-sectional area (CSA) and density of the muscle around the hip and adjacent SAT. Multivariable linear regression models were applied to assess the relationship between these parameters.

Results: Most increases in the density of the gluteus medius and minimus muscle (G.Med/MinM) were correlated with higher BMD in the femoral neck fracture (FNF) group with osteoporosis. In the FNF group, gluteus maximus muscle (G.MaxM) density was negatively associated with the BMD parameters of the proximal femur in individuals with osteoporosis, while they were positively associated with nonosteoporosis. In the intertrochanteric fracture (ITF) group without osteoporosis, both FN aBMD and FN vBMD showed significant correlations with G.Med/MinM density.

Discussion: In women with HFs, bone and muscle are closely related.

Conclusions: In older women with HFs, density but not CSA of the G.Med/MinM were associated with BMD parameters of the proximal femur. Osteoporosis may influence the relationship between G.MaxM density and proximal femur BMD in elderly women with FNF.

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髋部骨折老年妇女肌肉和皮下脂肪组织的大小和密度与股骨近端骨骼之间的关系。
背景:目的:探讨患有高血压的老年妇女肌肉和皮下脂肪组织(SAT)的大小和密度与股骨近端骨矿密度(BMD)之间的关系:对 661 名经历过低能急性高血压的女性参与者的髋部进行了定量计算机断层扫描(QCT),以测量平均骨密度(aBMD)和体积骨密度(vBMD)。此外,还测量了髋部和邻近 SAT 周围肌肉的横截面积 (CSA) 和密度。采用多变量线性回归模型评估这些参数之间的关系:结果:在股骨颈骨折(FNF)伴骨质疏松症组中,臀中肌和臀小肌密度(G.Med/MinM)的增加大多与较高的 BMD 相关。在股骨颈骨折组中,臀大肌(G.MaxM)密度与骨质疏松症患者股骨近端 BMD 参数呈负相关,而与非骨质疏松症患者呈正相关。在无骨质疏松症的转子间骨折(ITF)组中,FN aBMD 和 FN vBMD 均与 G.Med/MinM 密度呈显著相关:讨论:在患有高血压的女性中,骨骼和肌肉密切相关:在患有心房颤动的老年妇女中,G.Med/MinM 的密度与股骨近端 BMD 参数相关,但 CSA 与之无关。骨质疏松症可能会影响FNF老年妇女的G.MaxM密度与股骨近端BMD之间的关系。
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来源期刊
CiteScore
7.90
自引率
5.00%
发文量
283
审稿时长
1 months
期刊介绍: Aging clinical and experimental research offers a multidisciplinary forum on the progressing field of gerontology and geriatrics. The areas covered by the journal include: biogerontology, neurosciences, epidemiology, clinical gerontology and geriatric assessment, social, economical and behavioral gerontology. “Aging clinical and experimental research” appears bimonthly and publishes review articles, original papers and case reports.
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