Role of Yme1 in mitochondrial protein homeostasis: from regulation of protein import, OXPHOS function to lipid synthesis and mitochondrial dynamics.

IF 3.8 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochemical Society transactions Pub Date : 2024-06-26 DOI:10.1042/BST20240450
Kwan Ting Kan, Joel Wilcock, Hui Lu
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Abstract

Mitochondria are essential organelles of eukaryotic cells and thus mitochondrial proteome is under constant quality control and remodelling. Yme1 is a multi-functional protein and subunit of the homo-hexametric complex i-AAA proteinase. Yme1 plays vital roles in the regulation of mitochondrial protein homeostasis and mitochondrial plasticity, ranging from substrate degradation to the regulation of protein functions involved in mitochondrial protein biosynthesis, energy production, mitochondrial dynamics, and lipid biosynthesis and signalling. In this mini review, we focus on discussing the current understanding of the roles of Yme1 in mitochondrial protein import via TIM22 and TIM23 pathways, oxidative phosphorylation complex function, as well as mitochondrial lipid biosynthesis and signalling, as well as a brief discussion of the role of Yme1 in modulating mitochondrial dynamics.

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Yme1 在线粒体蛋白质平衡中的作用:从调节蛋白质导入、OXPHOS 功能到脂质合成和线粒体动力学。
线粒体是真核细胞的重要细胞器,因此线粒体蛋白质组不断受到质量控制和重塑。Yme1 是一种多功能蛋白质,也是同源六价复合物 i-AAA 蛋白酶的亚基。Yme1 在调控线粒体蛋白平衡和线粒体可塑性方面发挥着重要作用,包括从底物降解到调控线粒体蛋白生物合成、能量产生、线粒体动力学以及脂质生物合成和信号传导中的蛋白功能。在这篇小型综述中,我们将重点讨论目前对 Yme1 在通过 TIM22 和 TIM23 途径导入线粒体蛋白质、氧化磷酸化复合物功能以及线粒体脂质生物合成和信号传导中的作用的理解,并简要讨论 Yme1 在调节线粒体动力学中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biochemical Society transactions
Biochemical Society transactions 生物-生化与分子生物学
CiteScore
7.80
自引率
0.00%
发文量
351
审稿时长
3-6 weeks
期刊介绍: Biochemical Society Transactions is the reviews journal of the Biochemical Society. Publishing concise reviews written by experts in the field, providing a timely snapshot of the latest developments across all areas of the molecular and cellular biosciences. Elevating our authors’ ideas and expertise, each review includes a perspectives section where authors offer comment on the latest advances, a glimpse of future challenges and highlighting the importance of associated research areas in far broader contexts.
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