Association between polymorphisms in TLR3, TICAM1 and IFNA1 genes and covid-19 severity in Southern Brazil.

IF 3.9 3区医学 Q1 PATHOLOGY Expert Review of Molecular Diagnostics Pub Date : 2024-06-01 Epub Date: 2024-06-17 DOI:10.1080/14737159.2024.2367466

Matheus Braga, Mariana Akemi Sonoda Shiga, Pedro Emanuel Santiago Silva, Aléia Harumi Uchibaba Yamanaka, Victor Hugo Souza, Sergio Grava, Andréa Name Colado Simão, Janisleya Silva Ferreira Neves, Quirino Alves de Lima Neto, Joana Maira Valentini Zacarias, Jeane Eliete Laguila Visentainer

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Abstract

Background: A distinct phenotype in Coronavirus disease 2019 (Covid-19) was observed in severe patients, consisting of a highly impaired interferon (IFN) type I response, an exacerbated inflammatory response.

Objective: The aim of the present study was to investigate a possible association of single nucleotide polymorphisms (SNPs), in five genes related to the immune response, rs3775291 in TLR3; rs2292151 in TICAM1; rs1758566 in IFNA1; rs1800629 in TNF, and rs1800795 in IL6 with the severity of Covid-19.

Methods: A cross-sectional study was performed, with non-severe and severe/critical patients diagnosed with Covid-19, by two public hospitals in Brazil. In total, 300 patients were genotyped for the SNPs, 150 with the non-severe form of the disease and 150 with severe/critical form.

Results: The T/T genotype of TLR3 in recessive model shows 58% of protection against severe/critical Covid-19; as well as the genotypes G/A+A/A of TICAM1 in dominant model with 60% of protection, and in a codominant model G/A with 57% and A/A with 71% of protection against severe/critical Covid-19. Comparing severe and critical cases, the T/C genotype of IFNA1 in the codominant model and TC+C/C in the dominant model showed twice the risk of critical Covid-19.

Conclusion: We can conclude that rs3775291, rs2292151 and rs1758566 can influence the COVID-19 severity.

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巴西南部 TLR3、TICAM1 和 IFNA1 基因的多态性与 covid-19 严重程度之间的关系。

背景：在重症患者中观察到了冠状病毒病2019（Covid-19）的独特表型，包括干扰素（IFN）I型反应高度受损、炎症反应加剧：本研究旨在调查与免疫反应相关的五个基因中的单核苷酸多态性（SNPs）与Covid-19严重程度的可能关联：TLR3中的rs3775291、TICAM1中的rs2292151、IFNA1中的rs1758566、TNF中的rs1800629和IL6中的rs1800795：巴西两家公立医院对确诊为 Covid-19 的非重度和重度/危重患者进行了横断面研究。共对 300 名患者进行了 SNPs 基因分型，其中 150 名为非重症患者，150 名为重症/危重症患者：结果：TLR3的T/T基因型在隐性模型中显示对重症/危重型Covid-19的保护率为58%；TICAM1的G/A+A/A基因型在显性模型中显示对重症/危重型Covid-19的保护率为60%，在双显性模型中显示对重症/危重型Covid-19的保护率分别为G/A 57%和A/A 71%。比较重度和危重病例，在显性模型中 IFNA1 的 T/C 基因型和在显性模型中 TC+C/C 基因型显示出危重 Covid-19 风险的两倍：我们可以得出结论，rs3775291、rs2292151 和 rs1758566 会影响 Covid-19 的严重程度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Molecular Diagnostics 医学-病理学

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Expert Review of Molecular Diagnostics (ISSN 1473-7159) publishes expert reviews of the latest advancements in the field of molecular diagnostics including the detection and monitoring of the molecular causes of disease that are being translated into groundbreaking diagnostic and prognostic technologies to be used in the clinical diagnostic setting. Each issue of Expert Review of Molecular Diagnostics contains leading reviews on current and emerging topics relating to molecular diagnostics, subject to a rigorous peer review process; editorials discussing contentious issues in the field; diagnostic profiles featuring independent, expert evaluations of diagnostic tests; meeting reports of recent molecular diagnostics conferences and key paper evaluations featuring assessments of significant, recently published articles from specialists in molecular diagnostic therapy. Expert Review of Molecular Diagnostics provides the forum for reporting the critical advances being made in this ever-expanding field, as well as the major challenges ahead in their clinical implementation. The journal delivers this information in concise, at-a-glance article formats: invaluable to a time-constrained community.