Regulation of cell function and identity by cellular senescence.

IF 7.4 1区 生物学 Q1 CELL BIOLOGY Journal of Cell Biology Pub Date : 2024-08-05 Epub Date: 2024-06-12 DOI:10.1083/jcb.202401112
Anda Huna, Amélie Massemin, Gabriela Makulyte, Jean-Michel Flaman, Nadine Martin, David Bernard
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Abstract

During aging and in some contexts, like embryonic development, wound healing, and diseases such as cancer, senescent cells accumulate and play a key role in different pathophysiological functions. A long-held belief was that cellular senescence decreased normal cell functions, given the loss of proliferation of senescent cells. This view radically changed following the discovery of the senescence-associated secretory phenotype (SASP), factors released by senescent cells into their microenvironment. There is now accumulating evidence that cellular senescence also promotes gain-of-function effects by establishing, reinforcing, or changing cell identity, which can have a beneficial or deleterious impact on pathophysiology. These effects may involve both proliferation arrest and autocrine SASP production, although they largely remain to be defined. Here, we provide a historical overview of the first studies on senescence and an insight into emerging trends regarding the effects of senescence on cell identity.

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细胞衰老对细胞功能和特性的调节。
在衰老过程中,以及在胚胎发育、伤口愈合和癌症等疾病的某些情况下,衰老细胞会不断积累,并在不同的病理生理功能中发挥关键作用。长期以来,人们一直认为细胞衰老会降低细胞的正常功能,因为衰老细胞失去了增殖能力。随着衰老相关分泌表型(SASP)的发现--衰老细胞向其微环境释放的因子--这种观点发生了根本改变。现在有越来越多的证据表明,细胞衰老还能通过建立、强化或改变细胞特性来促进功能增益效应,从而对病理生理学产生有益或有害的影响。这些效应可能涉及增殖停滞和自分泌 SASP 的产生,尽管它们在很大程度上仍有待界定。在此,我们将对有关衰老的首次研究进行历史性概述,并深入探讨有关衰老对细胞特性影响的新趋势。
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来源期刊
Journal of Cell Biology
Journal of Cell Biology 生物-细胞生物学
CiteScore
12.60
自引率
2.60%
发文量
213
审稿时长
1 months
期刊介绍: The Journal of Cell Biology (JCB) is a comprehensive journal dedicated to publishing original discoveries across all realms of cell biology. We invite papers presenting novel cellular or molecular advancements in various domains of basic cell biology, along with applied cell biology research in diverse systems such as immunology, neurobiology, metabolism, virology, developmental biology, and plant biology. We enthusiastically welcome submissions showcasing significant findings of interest to cell biologists, irrespective of the experimental approach.
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