Measurement of Polyethylene Glycol 3350 With Standard Household Measuring Devices.

Q2 Medicine Journal of Pediatric Pharmacology and Therapeutics Pub Date : 2024-06-01 Epub Date: 2024-06-10 DOI:10.5863/1551-6776-29.3.286
Kristen R Nichols, Darcie D Streetman, Nicolette A Gordon, Chad A Knoderer
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Abstract

Objective: Though standard household measuring devices (e.g., teaspoons, tablespoons) are often used in clinical practice to measure pediatric doses of polyethylene glycol 3350 (PEG-3350), no published -literature documents the accuracy of these measurements. Standard dosing for adults is 17 grams, which is 1 capful according to the manufacturer. The objective of this study was to determine the weight of household teaspoons and tablespoons of PEG-3350.

Methods: PEG-3350 measurements were performed using 5 different household measuring teaspoons and tablespoons and the cap that accompanies the bottle for 3 different brands of PEG-3350. Using an electronic balance to determine weights, 3 investigators completed 5 measurements for each of the 5 measurement devices and PEG-3350 bottle caps as follows: leveled teaspoons and tablespoons, unleveled teaspoons and tablespoons, "heaping" tablespoons, half-capfuls, and capfuls.

Results: A leveled teaspoonful of PEG-3350 weighed ∼3.3 grams and an unleveled teaspoonful weighed ∼3.7 grams. A leveled, unleveled, and heaping tablespoon of PEG-3350 weighed about 10, 11, and 15 grams, respectively. Heaping tablespoons, half-capfuls, and capfuls resulted in the most measurement variability.

Conclusions: Use of a kitchen scale may be the most precise method of measurement, however not all patients have kitchen scales. Standard household measuring devices (teaspoons and tablespoons) may be used to conveniently measure PEG-3350 doses. Using 1 dedicated measurement device and leveling the dose may improve consistency, which could be beneficial for patients who are sensitive to dose variability.

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使用标准家用测量设备测量聚乙二醇 3350。
目的:虽然在临床实践中经常使用标准的家用测量设备(如茶匙、汤匙)来测量聚乙二醇 3350 (PEG-3350) 的儿科剂量,但没有公开发表的文献记录这些测量方法的准确性。根据生产商的说法,成人的标准剂量为 17 克,即 1 瓶盖。本研究的目的是确定家用茶匙和汤匙 PEG-3350 的重量:使用 5 种不同的家用茶匙和汤匙以及 3 种不同品牌 PEG-3350 的瓶盖测量 PEG-3350 的重量。3 名调查人员使用电子天平确定重量,分别对 5 种测量装置和 PEG-3350 瓶盖完成 5 次测量,具体如下:平整的茶匙和汤匙、不平整的茶匙和汤匙、"堆叠 "汤匙、半瓶和瓶盖:匀称的一茶匙 PEG-3350 重 3.3 克,未匀称的一茶匙重 3.7 克。一茶匙 PEG-3350 的重量分别为 10 克、11 克和 15 克。匙、半瓶装和瓶装的测量结果差异最大:结论:使用厨房秤可能是最精确的测量方法,但并非所有患者都有厨房秤。标准家用测量设备(茶匙和汤匙)可用于方便地测量 PEG-3350 剂量。使用一种专用的测量设备并将剂量调平可提高一致性,这对那些对剂量变化敏感的患者有益。
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来源期刊
Journal of Pediatric Pharmacology and Therapeutics
Journal of Pediatric Pharmacology and Therapeutics Medicine-Pediatrics, Perinatology and Child Health
CiteScore
2.40
自引率
0.00%
发文量
90
期刊介绍: The Journal of Pediatric Pharmacology and Therapeutics is the official journal of the Pediatric Pharmacy Advocacy Group. JPPT is a peer-reviewed multi disciplinary journal that is devoted to promoting the safe and effective use of medications in infants and children. To this end, the journal publishes practical information for all practitioners who provide care to pediatric patients. Each issue includes review articles, original clinical investigations, case reports, editorials, and other information relevant to pediatric medication therapy. The Journal focuses all work on issues related to the practice of pediatric pharmacology and therapeutics. The scope of content includes pharmacotherapy, extemporaneous compounding, dosing, methods of medication administration, medication error prevention, and legislative issues. The Journal will contain original research, review articles, short subjects, case reports, clinical investigations, editorials, and news from such organizations as the Pediatric Pharmacy Advocacy Group, the FDA, the American Academy of Pediatrics, the American Society of Health-System Pharmacists, and so on.
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