Pioneering Topical Ointment Intervention for Unprecedented Antimicrobial and Diabetic Wound Management with Phenylpropanoids and Nano-Silver.

IF 5 3区 医学 Q1 PHARMACOLOGY & PHARMACY AAPS Journal Pub Date : 2024-06-11 DOI:10.1208/s12248-024-00936-4
Hari Prasath Nagaiah, Priya Dharsini Periyakaruppan Murugesan, Chaughule Vrushali Ravindra Rupali, Karutha Pandian Shunmugiah
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Abstract

Addressing the intertwined challenges of antimicrobial resistance and impaired wound healing in diabetic patients, an oil/water emulsion-based nano-ointment integrating phenylpropanoids-Eugenol and Cinnamaldehyde-with positively-charged silver nanoparticles was synthesized. The process began with the synthesis and characterization of nano-silver, aimed at ensuring the effectiveness and safety of the nanoparticles in biological applications. Subsequent experiments determined the minimum inhibitory concentration (MIC) against pathogens such as Streptococcus aureus, Pseudomonas aeruginosa and Candida albicans. These MIC values of all three active leads guided the strategic formulation of an ointment base, which effectively integrated the bioactive components. Evaluations of this nano-ointment revealed enhanced antimicrobial activity against both clinical and reference bacterial strains and it maintained stability after freeze-thaw cycles. Furthermore, the ointment demonstrated superior in-vitro diabetic wound healing capabilities and significantly promoted angiogenesis, as shown by enhanced blood vessel formation in the Chorioallantoic Membrane assay. These findings underscore the formulation's therapeutic potential, marking a significant advance in the use of nanotechnology for topical wound care.

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开创性的局部软膏疗法,利用苯丙酸和纳米银实现前所未有的抗菌和糖尿病伤口管理。
为了应对糖尿病患者抗菌药耐药性和伤口愈合障碍的双重挑战,我们合成了一种基于油/水乳液的纳米药膏,它将苯丙醇和肉桂醛与带正电荷的纳米银粒子结合在一起。该过程从纳米银的合成和表征开始,旨在确保纳米粒子在生物应用中的有效性和安全性。随后的实验确定了对金黄色葡萄球菌、铜绿假单胞菌和白色念珠菌等病原体的最小抑菌浓度(MIC)。所有三种活性成分的 MIC 值指导了软膏基质的战略配方,有效地整合了生物活性成分。对这种纳米软膏的评估表明,它对临床菌株和参考菌株都具有更强的抗菌活性,而且在冻融循环后仍能保持稳定。此外,该软膏还显示出卓越的体外糖尿病伤口愈合能力,并能显著促进血管生成,这体现在绒毛膜试验中血管形成的增强。这些研究结果凸显了该配方的治疗潜力,标志着纳米技术在局部伤口护理领域的应用取得了重大进展。
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来源期刊
AAPS Journal
AAPS Journal 医学-药学
CiteScore
7.80
自引率
4.40%
发文量
109
审稿时长
1 months
期刊介绍: The AAPS Journal, an official journal of the American Association of Pharmaceutical Scientists (AAPS), publishes novel and significant findings in the various areas of pharmaceutical sciences impacting human and veterinary therapeutics, including: · Drug Design and Discovery · Pharmaceutical Biotechnology · Biopharmaceutics, Formulation, and Drug Delivery · Metabolism and Transport · Pharmacokinetics, Pharmacodynamics, and Pharmacometrics · Translational Research · Clinical Evaluations and Therapeutic Outcomes · Regulatory Science We invite submissions under the following article types: · Original Research Articles · Reviews and Mini-reviews · White Papers, Commentaries, and Editorials · Meeting Reports · Brief/Technical Reports and Rapid Communications · Regulatory Notes · Tutorials · Protocols in the Pharmaceutical Sciences In addition, The AAPS Journal publishes themes, organized by guest editors, which are focused on particular areas of current interest to our field.
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