The Burden of Cardiovascular Disease Attributable to Hypertension in Nigeria: A Modelling Study Using Summary-Level Data.

IF 3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Global Heart Pub Date : 2024-06-06 eCollection Date: 2024-01-01 DOI:10.5334/gh.1332

Adedayo E Ojo, Dike B Ojji, Diederick E Grobbee, Mark D Huffman, Sanne A E Peters

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Abstract

Background: Globally, cardiovascular disease (CVD) remains the leading cause of mortality and disability, with hypertension being the single most important modifiable risk factor. Hypertension is responsible for about 18% of global deaths from CVD, of which African regions are disproportionately affected, especially sub-Saharan Africa. This study assessed the burden of major CVD subtypes attributable to hypertension in Nigeria.

Methods: The population attributable fractions (PAF) for myocardial infarction, all strokes, ischaemic stroke and intracerebral haemorrhagic stroke attributable to hypertension in Nigeria were calculated using published results from the INTERHEART and INTERSTROKE studies and prevalence estimates of hypertension in Nigeria. PAF estimates were obtained for age, sex, and geopolitical zones.

Results: Overall, hypertension contributed to 13.2% of all myocardial infarctions and 24.6% of all strokes, including 21.6% of all ischaemic strokes and 33.1% of all intracerebral haemorrhagic strokes. Among men aged ≤55 years, the PAF for myocardial infarction ranged from 11.7% (North-West) to 14.6% (South-East), while in older men, it spanned 9.2% (North-West) to 11.9% (South-East). Among women aged ≤65 years, PAF varied from 18.6% (South-South) to 20.8% (South-East and North-Central), and among women aged >65 years, it ranged from 10.4% (South-South) to 12.7% (South-East).

Conclusion: Hypertension is a key contributor to the burden of CVD in Nigeria. Understanding the burden of hypertension in the Nigerian population overall and key subgroups is crucial to developing and implementing contextualised health policies to reduce the burden of CVD. Public health interventions and policies centred on hypertension will play a critical role in potentially alleviating the burden of cardiovascular diseases (CVD) in Nigeria.

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尼日利亚高血压导致的心血管疾病负担：使用摘要级数据进行建模研究。

背景：在全球范围内，心血管疾病（CVD）仍然是导致死亡和残疾的主要原因，而高血压是唯一最重要的可改变风险因素。在全球死于心血管疾病的人数中，约有 18% 是由高血压引起的，其中非洲地区受到的影响尤为严重，尤其是撒哈拉以南非洲地区。本研究评估了尼日利亚因高血压导致的主要心血管疾病亚型的负担：方法：利用已公布的 INTERHEART 和 INTERSTROKE 研究结果以及尼日利亚高血压患病率估计值，计算了尼日利亚高血压导致的心肌梗死、所有脑卒中、缺血性脑卒中和脑内出血性脑卒中的人群可归因分数（PAF）。得出了年龄、性别和地缘政治区的 PAF 估计值：结果：总体而言，高血压导致了13.2%的心肌梗死和24.6%的脑卒中，包括21.6%的缺血性脑卒中和33.1%的脑出血性脑卒中。在年龄小于 55 岁的男性中，心肌梗死的 PAF 从 11.7%（西北部）到 14.6%（东南部）不等，而老年男性的 PAF 则从 9.2%（西北部）到 11.9%（东南部）不等。在年龄小于 65 岁的女性中，PAF 从 18.6%（南部）到 20.8%（东南部和中北部）不等，在年龄大于 65 岁的女性中，PAF 从 10.4%（南部）到 12.7%（东南部）不等：结论：高血压是造成尼日利亚心血管疾病负担的主要因素。了解尼日利亚总体人口和主要亚群的高血压负担对于制定和实施因地制宜的卫生政策以减轻心血管疾病负担至关重要。以高血压为中心的公共卫生干预措施和政策将在减轻尼日利亚心血管疾病（CVD）负担方面发挥关键作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Global Heart Medicine-Cardiology and Cardiovascular Medicine

CiteScore

5.70

自引率

5.40%

发文量

审稿时长

5 weeks

期刊介绍： Global Heart offers a forum for dialogue and education on research, developments, trends, solutions and public health programs related to the prevention and control of cardiovascular diseases (CVDs) worldwide, with a special focus on low- and middle-income countries (LMICs). Manuscripts should address not only the extent or epidemiology of the problem, but also describe interventions to effectively control and prevent CVDs and the underlying factors. The emphasis should be on approaches applicable in settings with limited resources. Economic evaluations of successful interventions are particularly welcome. We will also consider negative findings if important. While reports of hospital or clinic-based treatments are not excluded, particularly if they have broad implications for cost-effective disease control or prevention, we give priority to papers addressing community-based activities. We encourage submissions on cardiovascular surveillance and health policies, professional education, ethical issues and technological innovations related to prevention. Global Heart is particularly interested in publishing data from updated national or regional demographic health surveys, World Health Organization or Global Burden of Disease data, large clinical disease databases or registries. Systematic reviews or meta-analyses on globally relevant topics are welcome. We will also consider clinical research that has special relevance to LMICs, e.g. using validated instruments to assess health-related quality-of-life in patients from LMICs, innovative diagnostic-therapeutic applications, real-world effectiveness clinical trials, research methods (innovative methodologic papers, with emphasis on low-cost research methods or novel application of methods in low resource settings), and papers pertaining to cardiovascular health promotion and policy (quantitative evaluation of health programs.