The potential Role of CYP2D6*10(c.100 C>T) Gene Polymorphism in Kidney Injury of Patients with Hypertension Complicated with Non-Elevated Cystatin C.

IF 3.4 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Cardiovascular Toxicology Pub Date : 2024-08-01 Epub Date: 2024-06-12 DOI:10.1007/s12012-024-09880-3
Yufeng Jiang, Kuangyi Wang, Xiaofei Mei, Yafeng Zhou
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Abstract

This study aims to investigate the potential role of CYP2D6*10 (c.100 C>T) gene polymorphism in renal function injury among hypertensive patients without elevated cystatin C. A cohort of hypertensive patients without elevated cystatin C was enrolled between 2021 and 2024 in the Fourth Affiliated Hospital of Soochow University, and their peripheral venous blood was used for total RNA extraction and CYP2D6*10 genotype analysis. Based on kidney injury status, patients were categorized into two groups, hypertensive patients with kidney injury (n = 94) and those without (n = 893). General characteristics such as age, gender and hyperlipemia were compared between the two groups. Multiple genotype models were investigated between the two groups, including allele models, dominant models, recessive models, co-dominant models, and super-dominant models. The results revealed that in the co-dominant gene model (CC vs. CT vs. TT), the risk of hypertension combined with renal injury was lower with the CT genotype compared to the CC genotype (Odds Ratio (OR) = 0.55, 95% Confidence Interval (CI) = 0.32-0.93, p = 0.02). In the overdominance model (CC + TT vs. CT), the risk of hypertension and renal injury in CC and CT genotypes was 0.42 times lower than that in the CT genotype (OR = 0.42, 95% CI = 0.27-0.64, p < 0.001). This study proposes CYP2D610 gene polymorphism as a potential predictor of renal function injury in hypertensive patients with normal cystatin C levels.

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CYP2D6*10(c.100 C>T)基因多态性在高血压并发胱抑素 C 非升高患者肾损伤中的潜在作用
本研究旨在探讨CYP2D6*10(c.100 C>T)基因多态性在无胱抑素C升高的高血压患者肾功能损伤中的潜在作用。2021年至2024年期间,苏州大学附属第四医院招募了一批无胱抑素C升高的高血压患者,用他们的外周静脉血进行总RNA提取和CYP2D6*10基因型分析。根据肾损伤状况,患者被分为两组,即有肾损伤的高血压患者(94 人)和无肾损伤的高血压患者(893 人)。两组患者的年龄、性别和高脂血症等一般特征进行了比较。研究了两组患者的多种基因型模式,包括等位基因模式、显性模式、隐性模式、共显性模式和超显性模式。结果显示,在共显性基因模型(CC vs. CT vs. TT)中,CT 基因型与 CC 基因型相比,高血压合并肾损伤的风险更低(Odds Ratio (OR) = 0.55, 95% Confidence Interval (CI) = 0.32-0.93, p = 0.02)。在超显性模型(CC + TT vs. CT)中,CC 和 CT 基因型患高血压和肾损伤的风险比 CT 基因型低 0.42 倍(OR = 0.42,95% CI = 0.27-0.64,P = 0.02)。
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来源期刊
Cardiovascular Toxicology
Cardiovascular Toxicology 医学-毒理学
CiteScore
6.60
自引率
3.10%
发文量
61
审稿时长
>12 weeks
期刊介绍: Cardiovascular Toxicology is the only journal dedicated to publishing contemporary issues, timely reviews, and experimental and clinical data on toxicological aspects of cardiovascular disease. CT publishes papers that will elucidate the effects, molecular mechanisms, and signaling pathways of environmental toxicants on the cardiovascular system. Also covered are the detrimental effects of new cardiovascular drugs, and cardiovascular effects of non-cardiovascular drugs, anti-cancer chemotherapy, and gene therapy. In addition, Cardiovascular Toxicology reports safety and toxicological data on new cardiovascular and non-cardiovascular drugs.
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