Clinical effect of regional citrate anticoagulation continuous renal replacement therapy in three patients with hypercalcemic crisis.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-06-01 Epub Date: 2024-06-13 DOI:10.1177/03913988241259963

Chunyan Wang, Shilong Xiang

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Abstract

In this study, we investigated the effectiveness of regional citrate anticoagulation continuous renal replacement therapy (RCA-CRRT) in reducing blood calcium levels in three patients with hypercalcemia crisis caused by different etiologies. The sodium citrate chelation of calcium ions was utilized as an anticoagulant for treating severely affected patients. By adjusting the citrate anticoagulant dose and monitoring treatment indicators, RCA-CRRT parameters were actively modified to alleviate the hypercalcemia crisis and provide time for surgery or specialized treatment. Two patients experienced rapid and effective reductions in blood calcium levels, allowing for further treatment, while the third patient exhibited a repeated increase in blood calcium, which eventually decreased after parathyroid adenoma resection, leading to clinical discharge. Our findings suggest that RCA-CRRT can help alleviate hypercalcemia crisis, stabilize the patient's internal environment, and provide valuable time for clinical treatment in cases of various medical conditions causing abnormal blood calcium elevations.

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三名高钙血症危象患者接受区域性枸橼酸抗凝持续肾脏替代疗法的临床效果。

在这项研究中，我们探讨了区域性枸橼酸钠抗凝持续肾脏替代疗法（RCA-CRRT）在降低三名不同病因引起的高钙血症危象患者血钙水平方面的有效性。枸橼酸钠螯合钙离子作为抗凝剂用于治疗严重患者。通过调整枸橼酸抗凝剂剂量和监测治疗指标，积极调整RCA-CRRT参数，缓解高钙血症危象，为手术或专科治疗提供时间。两名患者的血钙水平迅速有效下降，为进一步治疗创造了条件，而第三名患者则表现出血钙反复升高，最终在甲状旁腺腺瘤切除术后血钙下降，临床出院。我们的研究结果表明，RCA-CRRT 可以帮助缓解高钙血症危象，稳定患者的内环境，为各种疾病引起的血钙异常升高的临床治疗提供宝贵的时间。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.