Cancer Therapy-induced Dermatotoxicity as a Window to Understanding Skin Immunity

IF 2.5 3区 医学 Q2 HEMATOLOGY Hematology-Oncology Clinics of North America Pub Date : 2024-06-12 DOI:10.1016/j.hoc.2024.05.002
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癌症治疗诱发的皮肤毒性是了解皮肤免疫的一个窗口。
瘙痒、皮疹和其他各种形式的皮肤毒性是接受分子靶向疗法和免疫疗法的癌症患者最常见的不良反应。免疫检查点抑制剂、巨噬细胞靶向药物和表皮生长因子受体/MEK抑制剂不仅能发挥抗肿瘤作用,还能干扰皮肤免疫平衡所必需的分子通路。研究癌症疗法诱导的皮肤毒性有助于我们确定皮肤免疫的分子机制,加深对人体生物学的理解。本综述总结了从皮肤不良事件分析中获得的新的机理认识,并讨论了未来研究中有待填补的知识空白。
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来源期刊
CiteScore
4.10
自引率
0.00%
发文量
86
审稿时长
6-12 weeks
期刊介绍: Hematology/Oncology Clinics updates you on the latest trends in patient management, keeps you up to date on the newest advances, and provides a sound basis for choosing treatment options. Under the direction of an experienced guest editor, each issue focuses on a single topic in hematology and oncology, including hemostasis and thrombosis, molecular and cellular basis of hematology, coagulation disorders, and cancers—bone, gastrointestinal, head and neck, lymphomas, neuroendocrine, breast, renal cell, melanoma, and more.
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