Association between circulatory complement activation and hypertensive renal damage: a case-control study.

IF 3 3区医学 Q1 UROLOGY & NEPHROLOGY Renal Failure Pub Date : 2024-12-01 Epub Date: 2024-06-14 DOI:10.1080/0886022X.2024.2365396

Zhongli Wang, Tingting Zhang, Xinyu Wang, Jianlong Zhai, Lili He, Sai Ma, Qingjuan Zuo, Guorui Zhang, Yifang Guo

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Abstract

Objective: The aim of this study was to investigate the potential importance of complement system activation, with particular emphasis on the complement alternative pathway (AP), in the pathogenesis of hypertensive renal damage.

Methods: Serum complement C3, complement Factor H (CFH) and AP activation were assessed in 66 participants with established essential hypertension with renal damage (RD). Fifty-nine patients with age- and sex-matched essential hypertension without renal damage (NRD) and 58 healthy participants (normal) were selected.

Results: Our study revealed that C3 and AP50 continuously increased from normal to NRD to RD (p < 0.05, respectively), while CFH was significantly lower than that in NRD and healthy participants (p < 0.05, respectively). After multifactorial logistic regression analysis corrected for confounders, elevated serum C3 (p = 0.001) and decreased CFH (p < 0.001) were found to be independent risk factors for hypertension in healthy participants; elevated serum C3 (p = 0.034), elevated AP50 (p < 0.001), decreased CFH (p < 0.001), increased age (p = 0.011) and increased BMI (p = 0.013) were found to be independent risk factors for the progression of hypertension to hypertensive renal damage; elevated serum C3 (p = 0.017), elevated AP50 (p = 0.023), decreased CFH (p = 0.005) and increased age (p = 0.041) were found to be independent risk factors for the development of hypertensive renal damage in healthy participants.

Conclusion: Abnormal activation of complement, particularly complement AP, may be a risk factor for the development and progression of hypertensive renal damage.

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循环补体激活与高血压肾损伤之间的关系：一项病例对照研究。

研究目的本研究旨在探讨补体系统活化，尤其是补体替代途径（AP）在高血压肾损害发病机制中的潜在重要性：方法：对 66 名已确诊并伴有肾损害（RD）的原发性高血压患者的血清补体 C3、补体因子 H（CFH）和 AP 活化情况进行了评估。结果：我们的研究发现，补体C3和补体H因子AP的活化率分别为0.5%和0.5%：我们的研究发现，从正常到 NRD 再到 RD，C3 和 AP50 持续升高（p p = 0.001），CFH 降低（p p = 0.034）、AP50 升高（p p = 0.011）和 BMI 升高（p = 0.013）是高血压进展为高血压肾损害的独立危险因素；血清 C3 升高（p = 0.017）、AP50 升高（p = 0.023）、CFH 降低（p = 0.005）和年龄增加（p = 0.041）是健康参与者发生高血压肾损害的独立危险因素：结论：补体激活异常，尤其是补体AP，可能是高血压肾损害发生和发展的风险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Renal Failure 医学-泌尿学与肾脏学

CiteScore

3.90

自引率

13.30%

发文量

374

审稿时长

1 months

期刊介绍： Renal Failure primarily concentrates on acute renal injury and its consequence, but also addresses advances in the fields of chronic renal failure, hypertension, and renal transplantation. Bringing together both clinical and experimental aspects of renal failure, this publication presents timely, practical information on pathology and pathophysiology of acute renal failure; nephrotoxicity of drugs and other substances; prevention, treatment, and therapy of renal failure; renal failure in association with transplantation, hypertension, and diabetes mellitus.