Risk factors associated with multidrug-resistant tuberculosis in areas with a moderate tuberculosis burden.

IF 2.3 4区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH International Health Pub Date : 2024-06-14 DOI:10.1093/inthealth/ihae039

Noormohamad Mansoori, Bagher Pahlavanzadeh, Masoumeh Atarjalali

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Abstract

Background: The emergence of multidrug-resistant tuberculosis (MDR-TB) or rifampicin-resistant (RR) TB poses a significant challenge for TB control initiatives on a global scale. This study's aim was to estimate the incidence of MDR-/RR-TB and identify the risk factors associated with their incidence in four provinces in northern Iran.

Methods: Drug susceptibility testing was conducted using the proportion method on Lowenstein-Jensen media. The demographic and clinical data were collected from the Iranian TB registry.

Results: Among 1083 individuals diagnosed with TB, 27 (2.5%) were identified as having MDR-/RR-TB, while 73 cases (6.7%) were any drug resistant (ADR). The statistical analysis revealed a significant association between marital status and MDR-/RR-TB (p=0.003). In addition, significant associations were observed between ADR-TB and gender (p=0.035) and previous treatment for TB (p=0.02).

Conclusions: Our findings provide important information on the drug resistance pattern of Mycobacterium tuberculosis strains, as well as risk factors in northern Iran. Given the identified risk factors, creative approaches to promote treatment adherence in TB patients, particularly divorced/widowed women and individuals with a previous history of TB treatment, are required.

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中度结核病流行地区耐多药结核病的相关风险因素。

背景：耐多药结核病（MDR-TB）或耐利福平结核病（RR）的出现对全球范围内的结核病控制措施构成了重大挑战。本研究旨在估算伊朗北部四个省的 MDR-/RR-TB 发病率，并确定与之相关的风险因素：方法：采用比例法在 Lowenstein-Jensen 培养基上进行药敏试验。方法：采用洛文斯坦-简森培养基上的比例法进行药敏试验，并从伊朗结核病登记处收集人口统计学和临床数据：结果：在 1083 名确诊的肺结核患者中，27 例（2.5%）被确定为 MDR-/RR-TB 病例，73 例（6.7%）为任何耐药性（ADR）病例。统计分析显示，婚姻状况与 MDR-/RR-TB 之间存在显著关联（p=0.003）。此外，ADR-TB 与性别（p=0.035）和既往结核病治疗（p=0.02）之间也存在明显关联：我们的研究结果为了解伊朗北部结核分枝杆菌菌株的耐药性模式和风险因素提供了重要信息。鉴于已发现的风险因素，需要采取创新方法来促进结核病患者坚持治疗，尤其是离异/寡居妇女和曾接受过结核病治疗的人。

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来源期刊

International Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

4.50

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： International Health is an official journal of the Royal Society of Tropical Medicine and Hygiene. It publishes original, peer-reviewed articles and reviews on all aspects of global health including the social and economic aspects of communicable and non-communicable diseases, health systems research, policy and implementation, and the evaluation of disease control programmes and healthcare delivery solutions. It aims to stimulate scientific and policy debate and provide a forum for analysis and opinion sharing for individuals and organisations engaged in all areas of global health.