Elucidation of how the Mir-23-27-24 cluster regulates development and aging

Abstract

MicroRNAs (miRNAs) are pivotal regulators of gene expression and are involved in biological processes spanning from early developmental stages to the intricate process of aging. Extensive research has underscored the fundamental role of miRNAs in orchestrating eukaryotic development, with disruptions in miRNA biogenesis resulting in early lethality. Moreover, perturbations in miRNA function have been implicated in the aging process, particularly in model organisms such as nematodes and flies. miRNAs tend to be clustered in vertebrate genomes, finely modulating an array of biological pathways through clustering within a single transcript. Although extensive research of their developmental roles has been conducted, the potential implications of miRNA clusters in regulating aging remain largely unclear. In this review, we use the Mir-23-27-24 cluster as a paradigm, shedding light on the nuanced physiological functions of miRNA clusters during embryonic development and exploring their potential involvement in the aging process. Moreover, we advocate further research into the intricate interplay among miRNA clusters, particularly the Mir-23-27-24 cluster, in shaping the regulatory landscape of aging. MicroRNAs significantly influence everything from growth to aging. However, the specific roles of certain miRNA clusters, like Mir-23-27-24, in aging are less understood. This review investigates the Mir-23-27-24 cluster’s function in embryonic growth and possible aging regulation. It’s a comprehensive review of how the Mir-23-27-24 cluster affects vital biological processes and aging, combining existing research to fill knowledge gaps. The Mir-23-27-24 cluster includes miRNAs vital in development stages and linked to various diseases, including cancer. Researchers underline the cluster’s role in embryonic development and its overlooked role in aging. They explore how these miRNAs control gene expression and contribute to the complexity of biological functions. This study implies that miRNA clusters like Mir-23-27-24 could be crucial in aging, opening new paths for aging research and potential treatments for age-related diseases. This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author.