Treatment for dry age-related macular degeneration: where we stand in 2024.

IF 3 2区医学 Q1 OPHTHALMOLOGY Current Opinion in Ophthalmology Pub Date : 2024-09-01 Epub Date: 2024-06-13 DOI:10.1097/ICU.0000000000001064

Sydney Wheeler, Raziyeh Mahmoudzadeh, Jessica Randolph

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Abstract

Purpose of review: This review highlights treatment options, both under investigation and currently available, for the treatment of dry age-related macular degeneration (AMD). An update on current clinical studies for dry AMD has been summarized.

Recent findings: Advanced dry AMD, characterized by geographic atrophy (GA), is a leading cause of blindness in the developed world, though prior to 2023 there was no approved treatment. There are now two approved treatments in the United States for GA. Additionally, there are several studies and trials to investigate therapeutic potential and effects of therapies for earlier intervention in dry AMD. Approaches to therapy include inhibiting the complement system, utilizing gene therapy, stem cell therapy, laser therapy, and surgical implants.

Summary: While there has been notable prior advancement in the treatment for neovascular or wet AMD, for the first time there are Food and Drug Administration (FDA) approved treatments for GA. Clinical studies have shown promise for additional methods for managing dry AMD both medically and surgically.

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干性老年性黄斑变性的治疗：2024 年的现状。

综述目的：本综述重点介绍了治疗干性老年性黄斑变性（AMD）的研究中和现有的治疗方案。还总结了当前干性黄斑变性临床研究的最新进展：以地理萎缩（GA）为特征的晚期干性黄斑变性是发达国家致盲的主要原因之一，但在 2023 年之前还没有获得批准的治疗方法。目前，美国已批准了两种治疗 GA 的方法。此外，还有一些研究和试验正在调查早期干预干性老年黄斑变性的治疗潜力和效果。治疗方法包括抑制补体系统、利用基因疗法、干细胞疗法、激光疗法和手术植入等。摘要：虽然之前在治疗新生血管性或湿性 AMD 方面取得了显著进展，但美国食品和药物管理局（FDA）首次批准了治疗 GA 的方法。临床研究显示，通过药物和手术治疗干性老年黄斑变性的其他方法前景看好。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Ophthalmology 医学-眼科学

CiteScore

6.80

自引率

5.40%

发文量

120

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Ophthalmology is an indispensable resource featuring key up-to-date and important advances in the field from around the world. With renowned guest editors for each section, every bimonthly issue of Current Opinion in Ophthalmology delivers a fresh insight into topics such as glaucoma, refractive surgery and corneal and external disorders. With ten sections in total, the journal provides a convenient and thorough review of the field and will be of interest to researchers, clinicians and other healthcare professionals alike.