M Vittoria, E Horwell, D Bastoni, A Saggese, L Baccigalupi, S M Cutting, E Ricca
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引用次数: 0
Abstract
Chronic intestinal inflammation is associated with strong alterations of the microbial composition of the gut. Probiotic treatments and microbiota-targeting approaches have been considered to reduce the inflammation, improve both gut barrier function as well as overall gastrointestinal health. Here, a murine model of experimental colitis was used to assess the beneficial health effects of Bacillus subtilis SF106 and Bacillus clausii (recently renamed Shouchella clausii) SF174, two spore-forming strains previously characterised in vitro as potential probiotics. Experimental colitis was induced in BALB/c mice by the oral administration of dextran sodium sulphate (DSS) and groups of animals treated with spores of either strain. Spores of both strains reduced the DSS-induced inflammation with spores of B. clausii SF174 more effective than B. subtilis SF106. Spores of both strains remodelled the mouse gut microbiota favouring the presence of beneficial microbes such as members of the Bacteroidetes and Akkermansia genera.
期刊介绍:
Beneficial Microbes is a peer-reviewed scientific journal with a specific area of focus: the promotion of the science of microbes beneficial to the health and wellbeing of man and animal. The journal contains original research papers and critical reviews in all areas dealing with beneficial microbes in both the small and large intestine, together with opinions, a calendar of forthcoming beneficial microbes-related events and book reviews. The journal takes a multidisciplinary approach and focuses on a broad spectrum of issues, including safety aspects of pro- & prebiotics, regulatory aspects, mechanisms of action, health benefits for the host, optimal production processes, screening methods, (meta)genomics, proteomics and metabolomics, host and bacterial physiology, application, and role in health and disease in man and animal. Beneficial Microbes is intended to serve the needs of researchers and professionals from the scientific community and industry, as well as those of policy makers and regulators.
The journal will have five major sections:
* Food, nutrition and health
* Animal nutrition
* Processing and application
* Regulatory & safety aspects
* Medical & health applications
In these sections, topics dealt with by Beneficial Microbes include:
* Worldwide safety and regulatory issues
* Human and animal nutrition and health effects
* Latest discoveries in mechanistic studies and screening methods to unravel mode of action
* Host physiology related to allergy, inflammation, obesity, etc.
* Trends in application of (meta)genomics, proteomics and metabolomics
* New developments in how processing optimizes pro- & prebiotics for application
* Bacterial physiology related to health benefits