{"title":"The Role of Traditional Chinese Medicines in the Treatment of Osteoporosis.","authors":"Liang Wang, Xinyi Huang, Jinran Qin, Baoyu Qi, Chuanrui Sun, Xiangyun Guo, Qingqing Liu, Yichen Liu, Yong Ma, Xu Wei, Yili Zhang","doi":"10.1142/S0192415X24500393","DOIUrl":null,"url":null,"abstract":"<p><p>Osteoporosis (OP) represents a substantial public health issue and is associated with increasing rates of morbidity and mortality. It is characterized by reduced bone mineral density, deterioration of bone tissue quality, disruption of the microarchitecture of bones, and compromised bone strength. These changes may be attributed to the following factors: intercellular communication between osteoblasts and osteoclasts; imbalanced bone remodeling; imbalances between osteogenesis and adipogenesis; imbalances in hormonal regulation; angiogenesis; chronic inflammation; oxidative stress; and intestinal microbiota imbalances. Treating a single aspect of the disease is insufficient to address its multifaceted nature. In recent decades, traditional Chinese medicine (TCM) has shown great potential in the treatment of OP, and the therapeutic effects of Chinese patent drugs and Chinese medicinal herbs have been scientifically proven. TCMs, which contain multiple components, can target the diverse pathogeneses of OP through a multitargeted approach. Herbs such as XLGB, JTG, GSB, Yinyanghuo, Gusuibu, Buguzhi, and Nvzhenzi are among the TCMs that can be used to treat OP and have demonstrated promising effects in this context. They exert their therapeutic effects by targeting various pathways involved in bone metabolism. These TCMs balance the activity of osteoblasts (bone-forming cells) and osteoclasts (bone-resorbing cells), and they exhibit anti-inflammatory, immunomodulatory, anti-oxidative, and estrogen-like functions. These multifaceted mechanisms underlie the efficacy of these herbs in the management and treatment of OP. Herein, we examine the efficacy of various Chinese herbs and Chinese patent drugs in treating OP by reviewing previous clinical trials and basic experiments, and we examine the potential mechanism of these therapies to provide evidence regarding the use of TCM for treating OP.</p>","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":" ","pages":"949-986"},"PeriodicalIF":0.0000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The American journal of Chinese medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1142/S0192415X24500393","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/6/14 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Osteoporosis (OP) represents a substantial public health issue and is associated with increasing rates of morbidity and mortality. It is characterized by reduced bone mineral density, deterioration of bone tissue quality, disruption of the microarchitecture of bones, and compromised bone strength. These changes may be attributed to the following factors: intercellular communication between osteoblasts and osteoclasts; imbalanced bone remodeling; imbalances between osteogenesis and adipogenesis; imbalances in hormonal regulation; angiogenesis; chronic inflammation; oxidative stress; and intestinal microbiota imbalances. Treating a single aspect of the disease is insufficient to address its multifaceted nature. In recent decades, traditional Chinese medicine (TCM) has shown great potential in the treatment of OP, and the therapeutic effects of Chinese patent drugs and Chinese medicinal herbs have been scientifically proven. TCMs, which contain multiple components, can target the diverse pathogeneses of OP through a multitargeted approach. Herbs such as XLGB, JTG, GSB, Yinyanghuo, Gusuibu, Buguzhi, and Nvzhenzi are among the TCMs that can be used to treat OP and have demonstrated promising effects in this context. They exert their therapeutic effects by targeting various pathways involved in bone metabolism. These TCMs balance the activity of osteoblasts (bone-forming cells) and osteoclasts (bone-resorbing cells), and they exhibit anti-inflammatory, immunomodulatory, anti-oxidative, and estrogen-like functions. These multifaceted mechanisms underlie the efficacy of these herbs in the management and treatment of OP. Herein, we examine the efficacy of various Chinese herbs and Chinese patent drugs in treating OP by reviewing previous clinical trials and basic experiments, and we examine the potential mechanism of these therapies to provide evidence regarding the use of TCM for treating OP.
骨质疏松症(Osteoporosis,OP)是一个重大的公共卫生问题,其发病率和死亡率与日俱增。骨质疏松症的特点是骨矿物质密度降低、骨组织质量恶化、骨骼微结构破坏和骨强度受损。这些变化可归因于以下因素:成骨细胞和破骨细胞之间的细胞间交流、骨重塑失衡、成骨和脂肪生成失衡、激素调节失衡、血管生成、慢性炎症、氧化应激和肠道微生物群失衡。治疗疾病的单一方面不足以解决其多面性。近几十年来,传统中医药在治疗 OP 方面显示出巨大潜力,中成药和中草药的治疗效果已得到科学证实。中药含有多种成分,可通过多靶点方法针对 OP 的多种病原体。XLGB、JTG、GSB、Yinyanghuo、Gusuibu、Buguzhi 和 Nvzhenzi 等中草药可用于治疗 OP,并已显示出良好的效果。这些中药通过靶向参与骨代谢的各种途径发挥治疗作用。这些中药可平衡成骨细胞(骨形成细胞)和破骨细胞(骨吸收细胞)的活性,并具有抗炎、免疫调节、抗氧化和类似雌激素的功能。这些多方面的机制是这些草药在管理和治疗 OP 方面具有疗效的基础。在此,我们通过回顾以往的临床试验和基础实验,研究各种中草药和中成药在治疗 OP 方面的疗效,并探讨这些疗法的潜在机制,为使用中医药治疗 OP 提供证据。