PEGose Block Poly(lactic acid) Nanoparticles for Cargo Delivery

IF 5.1 1区化学 Q1 POLYMER SCIENCE Macromolecules Pub Date : 2024-06-14 DOI:10.1021/acs.macromol.4c00528

Jean-Baptiste Masclef, Emmanuelle M. N. Acs, Jesko Koehnke, Joëlle Prunet* and Bernhard V. K. J. Schmidt*,

引用次数: 0

Abstract

Hydrophilic polymers have found ubiquitous use in drug delivery and novel polymer materials to advance drug delivery systems are highly sought after. Herein, an amylose mimic (PEGose) was combined with poly(lactic acid) (PLA) in an amphiphilic block copolymer to form PEG-free nanoparticles as an alternative to PEG-based nanomedicines. The block copolymer self-assembled into 150–200 nm particles with a narrow dispersity in aqueous environment. The formed nanoparticles were capable of encapsulation, the sustained release of both hydrophilic and hydrophobic dyes. Moreover, the nanoparticles were found to be remarkably stable and had a very low cytotoxicity and a high propensity to penetrate cells. These results highlight the potential of PEGose-b-PLA to be used in drug delivery with a new hydrophilic building block.

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用于货物运输的 PEGose 嵌段聚（乳酸）纳米颗粒

亲水性聚合物在给药过程中的应用无处不在，而新型聚合物材料在推进给药系统方面的应用也备受追捧。在这里，一种淀粉糖模拟物（PEGose）与聚乳酸（PLA）结合成一种两亲性嵌段共聚物，形成不含 PEG 的纳米颗粒，作为基于 PEG 的纳米药物的替代品。嵌段共聚物在水环境中自组装成 150-200 nm 的颗粒，分散性较窄。所形成的纳米颗粒能够封装、持续释放亲水性和疏水性染料。此外，研究还发现这种纳米粒子非常稳定，细胞毒性极低，穿透细胞的能力很强。这些结果凸显了 PEGose-b-PLA 作为一种新型亲水性结构单元在药物递送方面的应用潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Macromolecules 工程技术-高分子科学

CiteScore

9.30

自引率

16.40%

发文量

942

审稿时长

2 months

期刊介绍： Macromolecules publishes original, fundamental, and impactful research on all aspects of polymer science. Topics of interest include synthesis (e.g., controlled polymerizations, polymerization catalysis, post polymerization modification, new monomer structures and polymer architectures, and polymerization mechanisms/kinetics analysis); phase behavior, thermodynamics, dynamic, and ordering/disordering phenomena (e.g., self-assembly, gelation, crystallization, solution/melt/solid-state characteristics); structure and properties (e.g., mechanical and rheological properties, surface/interfacial characteristics, electronic and transport properties); new state of the art characterization (e.g., spectroscopy, scattering, microscopy, rheology), simulation (e.g., Monte Carlo, molecular dynamics, multi-scale/coarse-grained modeling), and theoretical methods. Renewable/sustainable polymers, polymer networks, responsive polymers, electro-, magneto- and opto-active macromolecules, inorganic polymers, charge-transporting polymers (ion-containing, semiconducting, and conducting), nanostructured polymers, and polymer composites are also of interest. Typical papers published in Macromolecules showcase important and innovative concepts, experimental methods/observations, and theoretical/computational approaches that demonstrate a fundamental advance in the understanding of polymers.