Factors for predicting the outcome of surgery for non-eosinophilic chronic rhinosinusitis with nasal polyps

IF 5.8 2区 医学 Q1 ALLERGY Annals of Allergy Asthma & Immunology Pub Date : 2024-11-01 DOI:10.1016/j.anai.2024.05.023
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Abstract

Background

Despite the large patient base in Asia, the prognostic factors of patients with non-eosinophilic chronic rhinosinusitis with nasal polyps (CRSwNPs) remain largely undetermined.

Objective

To systematically investigate the predictive value of clinical and biological variables for non-eosinophilic CRSwNP.

Methods

A total of 51 patients with non-eosinophilic CRSwNP who underwent functional endoscopic surgery were recruited. Clinical information and assessment were comprehensively collected before and after surgery. A broad spectrum of biomarkers was measured in tissue homogenates using multiple assays. A random forest algorithm and stepwise logistic regression were used to construct clinical, biological, and combined models.

Results

A total of 41.2% patients with non-eosinophilic CRSwNP were uncontrolled more than 6 months after surgery. We identified 1 clinical variable (22-item Sino-Nasal Outcome Test score) and 4 biomarkers (programmed cell death ligand 1, platelet-derived growth factor subunit β [PDGF-β], macrophage inflammatory protein-3b, and PDGF-α) that were significantly predictive of the surgical outcome. The clinical, biological, and combined models had predictive ability with areas under the curve of 0.78, 0.83, and 0.89, respectively. PDGF-β and programmed cell death ligand 1 were identified as independent biomarkers for the prognosis of patients with CRSwNP without considerable eosinophilic infiltration.

Conclusion

This study reveals that clinical and biological factors, such as the 22-item Sino-Nasal Outcome Test score and PDGF-β, are predictive of the postfunctional endoscopic surgical prognosis of patients with non-eosinophilic CRSwNP.
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非嗜酸性慢性鼻炎伴鼻息肉手术疗效的预测因素。
背景:尽管亚洲患者人数众多,但非嗜酸性慢性鼻炎伴鼻息肉(CRSwNP)患者的预后因素在很大程度上仍未确定:尽管亚洲患者人数众多,但非嗜酸性慢性鼻炎伴鼻息肉(CRSwNP)患者的预后因素在很大程度上仍未确定:我们旨在系统研究非嗜酸性粒细胞慢性鼻炎伴鼻息肉的临床和生物学变量的预测价值:我们招募了 51 名接受功能性内窥镜手术的非嗜酸性 CRSwNP 患者。全面收集了手术前后的临床信息和评估结果。使用多种检测方法测量了组织匀浆中的多种生物标记物。采用随机森林算法和逐步逻辑回归法构建临床、生物和综合模型:结果:41.2%的非嗜酸性粒细胞 CRSwNP 患者在术后超过 6 个月仍未得到控制。我们发现一个临床变量(22 项中国鼻科结果测试评分)和四个生物标志物(程序性细胞死亡配体 1、血小板衍生生长因子亚基 B [PDGF-β]、巨噬细胞炎症蛋白-3b 和 PDGF-α)对手术结果有显著的预测作用。临床模型、生物模型和综合模型的预测能力曲线下面积分别为 0.78、0.83 和 0.89。PDGF-β和程序性细胞死亡配体1被认为是预测无大量嗜酸性粒细胞浸润的CRSwNP患者预后的独立生物标志物:本研究表明,临床和生物学因素,如 22 项中鼻结局测试评分和 PDGF-β,可预测无大量嗜酸性粒细胞浸润的 CRSwNP 患者功能性内镜手术后的预后。
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来源期刊
CiteScore
6.50
自引率
6.80%
发文量
437
审稿时长
33 days
期刊介绍: Annals of Allergy, Asthma & Immunology is a scholarly medical journal published monthly by the American College of Allergy, Asthma & Immunology. The purpose of Annals is to serve as an objective evidence-based forum for the allergy/immunology specialist to keep up to date on current clinical science (both research and practice-based) in the fields of allergy, asthma, and immunology. The emphasis of the journal will be to provide clinical and research information that is readily applicable to both the clinician and the researcher. Each issue of the Annals shall also provide opportunities to participate in accredited continuing medical education activities to enhance overall clinical proficiency.
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Corrigendum to <'A systematic review and expert Delphi Consensus recommendation on the use of vaccines in patients receiving dupilumab: A position paper of the American College of Allergy, Asthma and Immunology'> <[Annals of Allergy, Asthma & Immunology 133 (2024) 286-94]>. Table of Contents Editorial Board Author Index Factors for predicting the outcome of surgery for non-eosinophilic chronic rhinosinusitis with nasal polyps
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