Migraine Risk in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder: A Nationwide Cohort Study in South Korea.

IF 3.2 3区医学 Q2 CLINICAL NEUROLOGY Neuroepidemiology Pub Date : 2024-06-14 DOI:10.1159/000539801

Yeon Hak Chung, Kyung-Do Han, Jin Hyung Jung, Soonwook Kwon, Eun Bin Cho, Junhee Park, Dong Wook Shin, Ju-Hong Min

{"title":"Migraine Risk in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder: A Nationwide Cohort Study in South Korea.","authors":"Yeon Hak Chung, Kyung-Do Han, Jin Hyung Jung, Soonwook Kwon, Eun Bin Cho, Junhee Park, Dong Wook Shin, Ju-Hong Min","doi":"10.1159/000539801","DOIUrl":null,"url":null,"abstract":"Introduction: Although the relationship between migraine and multiple sclerosis (MS) has been reported, the risk of migraine in MS and neuromyelitis optica spectrum disorder (NMOSD) is unclear. Therefore, this study investigated the risk of migraine in the Korean MS and NMOSD populations.Methods: This study analyzed claims data from 1,492 patients with MS and 1,551 patients with NMOSD based on diagnostic codes in the Korean National Health Insurance Service. Migraine risk was compared with a control group (matched 1:5 for age, sex, and comorbidities) using Cox proportional hazards analysis. Patients aged <20 years and with previous migraine were excluded.Results: Migraine risk was higher in patients with MS (adjusted hazard ratio [aHR] 1.37; 95% confidence interval [CI]: 1.15-1.62) but did not differ significantly in patients with NMOSD (aHR 1.05; 95% CI: 0.87-1.27) compared to controls. No significant sex-based differences in migraine risk were observed. Patients with NMOSD showed decreasing risk with age (p for interaction = 0.040). Comorbidities like hypertension, diabetes, or dyslipidemia did not significantly alter migraine risk in either group.Conclusion: The study results revealed an increased risk of migraines in patients with MS but not in patients with NMSOD compared with matched controls.","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-9"},"PeriodicalIF":3.2000,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuroepidemiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000539801","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: Although the relationship between migraine and multiple sclerosis (MS) has been reported, the risk of migraine in MS and neuromyelitis optica spectrum disorder (NMOSD) is unclear. Therefore, this study investigated the risk of migraine in the Korean MS and NMOSD populations.

Methods: This study analyzed claims data from 1,492 patients with MS and 1,551 patients with NMOSD based on diagnostic codes in the Korean National Health Insurance Service. Migraine risk was compared with a control group (matched 1:5 for age, sex, and comorbidities) using Cox proportional hazards analysis. Patients aged <20 years and with previous migraine were excluded.

Results: Migraine risk was higher in patients with MS (adjusted hazard ratio [aHR] 1.37; 95% confidence interval [CI]: 1.15-1.62) but did not differ significantly in patients with NMOSD (aHR 1.05; 95% CI: 0.87-1.27) compared to controls. No significant sex-based differences in migraine risk were observed. Patients with NMOSD showed decreasing risk with age (p for interaction = 0.040). Comorbidities like hypertension, diabetes, or dyslipidemia did not significantly alter migraine risk in either group.

Conclusion: The study results revealed an increased risk of migraines in patients with MS but not in patients with NMSOD compared with matched controls.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

多发性硬化症和神经性脊髓炎谱系障碍中的偏头痛风险：韩国全国队列研究》。

导言：虽然偏头痛与多发性硬化症（MS）之间的关系已有报道，但多发性硬化症和神经性脊髓炎视神经谱系障碍（NMOSD）中偏头痛的风险尚不清楚。因此，本研究调查了韩国 MS 和 NMOSD 患者偏头痛的风险：本研究分析了 1492 名多发性硬化症患者和 1551 名 NMOSD 患者的理赔数据，这些数据基于韩国国民健康保险服务的诊断代码。采用 Cox 比例危险分析法将偏头痛风险与对照组（年龄、性别和合并症匹配度为 1:5）进行了比较。年龄为20岁或曾患偏头痛的患者被排除在外：结果：与对照组相比，多发性硬化症患者的偏头痛风险较高（调整后危险比 [aHR] 1.37；95% 置信区间 [CI]：1.15-1.62），但 NMOSD 患者的偏头痛风险无显著差异（aHR 1.05；95%CI：0.87-1.27）。在偏头痛风险方面没有观察到明显的性别差异。NMOSD患者的偏头痛风险随年龄的增长而降低（交互作用 p=0.040）。高血压、糖尿病或血脂异常等并发症并未明显改变两组患者的偏头痛风险：研究结果表明，与匹配的对照组相比，多发性硬化症患者的偏头痛风险增加，但 NMSOD 患者的偏头痛风险没有增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Neuroepidemiology 医学-公共卫生、环境卫生与职业卫生

CiteScore

9.90

自引率

1.80%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Neuroepidemiology'' is the only internationally recognised peer-reviewed periodical devoted to descriptive, analytical and experimental studies in the epidemiology of neurologic disease. The scope of the journal expands the boundaries of traditional clinical neurology by providing new insights regarding the etiology, determinants, distribution, management and prevention of diseases of the nervous system.