{"title":"Precision single-atom editing: new frontiers in nitrogen insertion and substitution for the generation of N-heterocycles","authors":"Xue Li, Jia Xu and Zhi-Gang Xu","doi":"10.1039/D4QO00812J","DOIUrl":null,"url":null,"abstract":"<p >Single-atom editing, which involves precise modifications to a ring system through the selective insertion, deletion or substitution of atoms, represents a crucial advancement in the manipulation of chemically active molecules. This review focuses primarily on the editing of nitrogen atoms, including the insertion of N, the substitution of C with N and <small><sup>14</sup></small>N with <small><sup>15</sup></small>N for the construction of N-heterocycles. The emphasis on the nitrogen source facilitates a deeper understanding of the reactions involved. We anticipate that this review will not only underscore the innovative and enabling capabilities of current nitrogen single-atom editing techniques but also highlight the significant opportunities and untapped possibilities within this emerging and valuable field.</p>","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic Chemistry Frontiers","FirstCategoryId":"92","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2024/qo/d4qo00812j","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
Single-atom editing, which involves precise modifications to a ring system through the selective insertion, deletion or substitution of atoms, represents a crucial advancement in the manipulation of chemically active molecules. This review focuses primarily on the editing of nitrogen atoms, including the insertion of N, the substitution of C with N and 14N with 15N for the construction of N-heterocycles. The emphasis on the nitrogen source facilitates a deeper understanding of the reactions involved. We anticipate that this review will not only underscore the innovative and enabling capabilities of current nitrogen single-atom editing techniques but also highlight the significant opportunities and untapped possibilities within this emerging and valuable field.
单原子编辑涉及通过选择性地插入、删除或替换原子对环状系统进行精确修改,是化学活性分子操作方面的一项重要进展。本综述主要侧重于氮原子的编辑,包括插入 N、用 N 替换 C 和用 15N 替换 14N 以构建 N 杂环。对氮源的强调有助于加深对相关反应的理解。我们预计,这篇综述不仅将强调当前氮单原子编辑技术的创新和赋能能力,还将突出这一新兴和有价值领域的重大机遇和尚未开发的可能性。
期刊介绍:
Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.