Pathological mechanism of immune disorders in diabetic kidney disease and intervention strategies

IF 5.5 3区 材料科学 Q2 CHEMISTRY, PHYSICAL ACS Applied Energy Materials Pub Date : 2024-06-15 DOI:10.4239/wjd.v15.i6.1111
Tong Zhou, Yi-Lin Fang, Tian-Tian Tian, Gui-Xia Wang
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Abstract

Diabetic kidney disease is one of the most severe chronic microvascular complications of diabetes and a primary cause of end-stage renal disease. Clinical studies have shown that renal inflammation is a key factor determining kidney damage during diabetes. With the development of immunological technology, many studies have shown that diabetic nephropathy is an immune complex disease, and that most patients have immune dysfunction. However, the immune response associated with diabetic nephropathy and autoimmune kidney disease, or caused by ischemia or infection with acute renal injury, is different, and has a com-plicated pathological mechanism. In this review, we discuss the pathogenesis of diabetic nephropathy in immune disorders and the intervention mechanism, to provide guidance and advice for early intervention and treatment of diabetic nephropathy.
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糖尿病肾病免疫紊乱的病理机制及干预策略
糖尿病肾病是糖尿病最严重的慢性微血管并发症之一,也是终末期肾病的主要病因。临床研究表明,肾脏炎症是决定糖尿病肾损害的关键因素。随着免疫学技术的发展,许多研究表明,糖尿病肾病是一种免疫复合物疾病,大多数患者存在免疫功能障碍。然而,糖尿病肾病与自身免疫性肾病、缺血或感染引起的急性肾损伤相关的免疫反应是不同的,具有复杂的病理机制。在这篇综述中,我们探讨了糖尿病肾病在免疫紊乱中的发病机制和干预机制,为糖尿病肾病的早期干预和治疗提供指导和建议。
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来源期刊
ACS Applied Energy Materials
ACS Applied Energy Materials Materials Science-Materials Chemistry
CiteScore
10.30
自引率
6.20%
发文量
1368
期刊介绍: ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.
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