Finger-operated pumping platform for microfluidic preparation of nanoparticles

IF 2.3 4区 工程技术 Q2 INSTRUMENTS & INSTRUMENTATION Microfluidics and Nanofluidics Pub Date : 2024-06-14 DOI:10.1007/s10404-024-02738-8
Ahmed Azmeer, Ibraheem Kanan, Ghaleb A. Husseini, Mohamed Abdelgawad
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Abstract

Microfluidic preparation of nanoparticles (NPs) offers many advantages over traditional bench-top preparation techniques, including better control over particle size and higher uniformity. Although many studies have reported the use of low-cost microfluidic chips for nanoparticle synthesis, the technology is still expensive due to the high cost of the pumps needed to generate the required flows inside microchannels. Here, we present a low-cost finger-operated constant-pressure pumping platform capable of generating pressures as high as 120 kPa using finger-operated pumping caps that can be attached to any pop bottle. The platform costs around $208 and enables the generation of flow rate ratios (FRR) of up to 47:1 for the continuous flow synthesis of NPs. The pump has a resolution of 500 Pa per stroke and exhibits stable pressures for up to a few hours. To show the functionality of the proposed pump, we used it to prepare pegylated liposomes and poly lactic-co-glycolic acid (PLGA) nanoparticles with sizes ranging from 47 nm to 250 nm with an average polydispersity of 20% using commercially available micromixer chips and in-house made hydrodynamic flow focusing devices. We believe this platform will render microfluidic preparation of NPs accessible to any laboratory with minimal capabilities.

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用于微流控制备纳米粒子的指控泵平台
与传统的台式制备技术相比,微流体制备纳米粒子(NPs)具有许多优势,包括更好地控制粒度和更高的均匀性。尽管许多研究都报道了使用低成本微流控芯片合成纳米粒子的方法,但由于在微通道内产生所需流量所需的泵成本高昂,因此该技术的成本仍然很高。在这里,我们展示了一种低成本的手指操作恒压泵平台,利用可连接到任何汽水瓶上的手指操作泵盖,能够产生高达 120 kPa 的压力。该平台的成本约为 208 美元,能够产生高达 47:1 的流速比 (FRR),用于 NPs 的连续流合成。该泵每个冲程的分辨率为 500 Pa,压力稳定时间长达数小时。为了展示所建议的泵的功能,我们使用它制备了聚乙二醇化脂质体和聚乳酸-聚乙二醇酸(PLGA)纳米粒子,这些粒子的尺寸从 47 纳米到 250 纳米不等,平均多分散性为 20%,使用的是市售的微混合器芯片和内部制造的流体动力流聚焦装置。我们相信,这一平台将使任何实验室都能以最低限度的能力进行 NPs 的微流控制备。
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来源期刊
Microfluidics and Nanofluidics
Microfluidics and Nanofluidics 工程技术-纳米科技
CiteScore
4.80
自引率
3.60%
发文量
97
审稿时长
2 months
期刊介绍: Microfluidics and Nanofluidics is an international peer-reviewed journal that aims to publish papers in all aspects of microfluidics, nanofluidics and lab-on-a-chip science and technology. The objectives of the journal are to (1) provide an overview of the current state of the research and development in microfluidics, nanofluidics and lab-on-a-chip devices, (2) improve the fundamental understanding of microfluidic and nanofluidic phenomena, and (3) discuss applications of microfluidics, nanofluidics and lab-on-a-chip devices. Topics covered in this journal include: 1.000 Fundamental principles of micro- and nanoscale phenomena like, flow, mass transport and reactions 3.000 Theoretical models and numerical simulation with experimental and/or analytical proof 4.000 Novel measurement & characterization technologies 5.000 Devices (actuators and sensors) 6.000 New unit-operations for dedicated microfluidic platforms 7.000 Lab-on-a-Chip applications 8.000 Microfabrication technologies and materials Please note, Microfluidics and Nanofluidics does not publish manuscripts studying pure microscale heat transfer since there are many journals that cover this field of research (Journal of Heat Transfer, Journal of Heat and Mass Transfer, Journal of Heat and Fluid Flow, etc.).
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