Practical Applications of Supramolecular Macrocyclic Hosts in the Field of Herbal Medicines

IF 2.3 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Israel Journal of Chemistry Pub Date : 2024-06-14 DOI:10.1002/ijch.202300179

Huijuan Yu, Kejing Niu, Yuting Zhao, Yuefei Wang

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Abstract

Herbal medicines (HMs) are gaining increasing popularity and recognition worldwide due to their eco-friendliness and efficacy. With their multi-compounds, multi-targets, and multi-pathways characteristics, HMs have been used in treatment of various diseases. However, the clinical applications of preparations containing HMs have been limited due to their inherent physicochemical properties, including low water solubility, poor stability, and unsatisfactory bioavailability of bioactive compounds. Supramolecular macrocyclic hosts, like cyclodextrins, calixarenes, cucurbiturils, and pillararenes, are important objects of researches in supramolecular chemistry. These hosts have been utilized to encapsulate the ingredients, improve the solubility of poorly water-soluble components, enhance the stability of the tested compounds, increase the bioavailability of bioactive compounds, and ensure the safety of HMs. Herein, we provide a brief introduction to the theories of supramolecular chemistry and summarize the extensive applications of supramolecular macrocyclic hosts in the field of HMs. These applications encompass the screening of bioactive compounds in HMs and the enhancement of druggability for HMs. We hope this review can provide a strategy for dealing with the challenges of HMs, thereby enabling their better applications and development.

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超分子大环宿主在中草药领域的实际应用

草药（HMs）因其生态友好性和疗效日益受到全世界的欢迎和认可。HMs 具有多化合物、多靶点和多途径的特点，已被用于治疗各种疾病。然而，由于其固有的理化特性，包括水溶性低、稳定性差、生物活性化合物的生物利用度不理想等，含有 HMs 的制剂的临床应用一直受到限制。超分子大环宿主，如环糊精、钙烯、葫芦烯和支柱烯，是超分子化学研究的重要对象。这些宿主被用来封装成分，改善水溶性差的成分的溶解性，提高被测化合物的稳定性，增加生物活性化合物的生物利用度，并确保 HMs 的安全性。在此，我们简要介绍了超分子化学理论，并总结了超分子大环宿主在 HMs 领域的广泛应用。这些应用包括在 HMs 中筛选生物活性化合物和提高 HMs 的可药性。我们希望这篇综述能为应对 HMs 的挑战提供策略，从而使 HMs 得到更好的应用和发展。

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来源期刊

Israel Journal of Chemistry 化学-化学综合

CiteScore

6.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The fledgling State of Israel began to publish its scientific activity in 1951 under the general heading of Bulletin of the Research Council of Israel, which quickly split into sections to accommodate various fields in the growing academic community. In 1963, the Bulletin ceased publication and independent journals were born, with Section A becoming the new Israel Journal of Chemistry. The Israel Journal of Chemistry is the official journal of the Israel Chemical Society. Effective from Volume 50 (2010) it is published by Wiley-VCH. The Israel Journal of Chemistry is an international and peer-reviewed publication forum for Special Issues on timely research topics in all fields of chemistry: from biochemistry through organic and inorganic chemistry to polymer, physical and theoretical chemistry, including all interdisciplinary topics. Each topical issue is edited by one or several Guest Editors and primarily contains invited Review articles. Communications and Full Papers may be published occasionally, if they fit with the quality standards of the journal. The publication language is English and the journal is published twelve times a year.

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