{"title":"The Role of Betulin and its Derivative in Wound Healing and their Clinical\nProperties","authors":"Esteban Zavaleta‐Monestel, Jonathan García-Montero, Sebastián Arguedas‐Chacón, Carolina Rojas-Chinchilla, Ricardo Quesada-Villaseñor, Renato Murillo","doi":"10.2174/0115748855311705240530073557","DOIUrl":null,"url":null,"abstract":"\n\nCurrently, studies on various natural products that aid in wound healing have seen significant\ngrowth. Betulin and its derivative, betulinic acid, are triterpenes abundant in the leaves and barks\nof certain species, such as birch, which has been of particular interest. Clinical and preclinical studies\nhave demonstrated their ability to accelerate wound healing, as well as other properties such as antimicrobial,\nanti-inflammatory action, and anti-cancer properties, and beneficial effects on HIV, diabetes\nmellitus, and cardiovascular disorders. However, further research focusing exclusively on betulin\nand betulinic acid is needed to better understand its therapeutic potential and develop new medications\nfor effective management. These advancements could greatly enhance the treatment of\nwounds, skin lesions and other diseases, offering more effective and safer therapeutic options to improve\nthe quality of life of the population.\n","PeriodicalId":0,"journal":{"name":"","volume":"56 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/0115748855311705240530073557","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Currently, studies on various natural products that aid in wound healing have seen significant
growth. Betulin and its derivative, betulinic acid, are triterpenes abundant in the leaves and barks
of certain species, such as birch, which has been of particular interest. Clinical and preclinical studies
have demonstrated their ability to accelerate wound healing, as well as other properties such as antimicrobial,
anti-inflammatory action, and anti-cancer properties, and beneficial effects on HIV, diabetes
mellitus, and cardiovascular disorders. However, further research focusing exclusively on betulin
and betulinic acid is needed to better understand its therapeutic potential and develop new medications
for effective management. These advancements could greatly enhance the treatment of
wounds, skin lesions and other diseases, offering more effective and safer therapeutic options to improve
the quality of life of the population.
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