Jia-Qiang Wu, Wei Lin, Yifei Qu, Mei Xie, Huixuan Zhu, Jinhui Hu, Zhuang Xiong, Jun Xu, Wenhua Chen
{"title":"Rh(III)-Catalyzed Redox-neutral C-H Multifluoroalkenylation of Benzamides","authors":"Jia-Qiang Wu, Wei Lin, Yifei Qu, Mei Xie, Huixuan Zhu, Jinhui Hu, Zhuang Xiong, Jun Xu, Wenhua Chen","doi":"10.1055/a-2343-0676","DOIUrl":null,"url":null,"abstract":"Fluorinated molecules are widely used in pharmaceutical and agrochemical industries. Multifluoroalkyl-containing compounds have attracted increasing attention for their unique ability to alter the activity of drugs and bioactive molecules. Herein, we report an efficient Rh(III)-catalyzed redox-neutral C-H multifluoroalkenylation of benzamides with multifluoroalkenes, which provides a versatile protocol for accessing a wide range of multifluoroalkenylated arenes.","PeriodicalId":501298,"journal":{"name":"Synthesis","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Synthesis","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1055/a-2343-0676","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Fluorinated molecules are widely used in pharmaceutical and agrochemical industries. Multifluoroalkyl-containing compounds have attracted increasing attention for their unique ability to alter the activity of drugs and bioactive molecules. Herein, we report an efficient Rh(III)-catalyzed redox-neutral C-H multifluoroalkenylation of benzamides with multifluoroalkenes, which provides a versatile protocol for accessing a wide range of multifluoroalkenylated arenes.
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