The Impact of Opium Consumption on Inflammatory Factors in Umbilical Cord Blood and Maternal Blood Postpartum: A Potential Contributor to Neonatal Complications

IF 17.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-06-10 DOI:10.1177/00220426241259374

S. Khayat, H. Fanaei, Farideh Riki, Shahindokht Navabi Rigi, Ebrahim Alijani

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Abstract

Opium addiction during pregnancy can have significant effects on the activity of the immune system as well as on pregnancy outcomes. A study was conducted comparing opium-addicted pregnant women to healthy pregnant women. Blood samples were taken from the maternal vein and umbilical cord immediately after delivery to measure concentrations of inflammatory markers. The results showed that the opium-addicted group had significantly higher levels of IL-6, IL-10, CRP, C3, and C4 in both maternal and cord blood samples compared to the control group. Additionally, adverse pregnancy outcomes such as NICU admissions, neonatal deaths, and low Apgar scores were more prevalent in the opium-addicted group. These findings suggest that opium addiction during pregnancy can lead to postpartum inflammation and negatively impact pregnancy outcomes. It is important to address opium addiction and provide appropriate support and treatment to pregnant women to improve pregnancy outcomes and reduce the risk of complications.

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吸食鸦片对产后脐带血和产妇血液中炎症因子的影响：新生儿并发症的潜在诱因

怀孕期间吸食鸦片会对免疫系统的活动和妊娠结果产生重大影响。一项研究将吸食鸦片的孕妇与健康孕妇进行了比较。研究人员在孕妇分娩后立即从母体静脉和脐带抽取血液样本，以测量炎症标志物的浓度。结果显示，与对照组相比，鸦片成瘾组孕妇和脐带血样本中的 IL-6、IL-10、CRP、C3 和 C4 水平明显更高。此外，鸦片成瘾组的不良妊娠结局，如入住新生儿重症监护室、新生儿死亡和低Apgar评分更为普遍。这些研究结果表明，孕期吸食鸦片成瘾会导致产后炎症，并对妊娠结局产生负面影响。必须解决鸦片成瘾问题，并为孕妇提供适当的支持和治疗，以改善妊娠结局，降低并发症风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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