The challenge and opportunity of gut microbiota-targeted nanomedicine for colorectal cancer therapy

IF 23.7 Q1 MICROBIOLOGY iMeta Pub Date : 2024-06-10 DOI:10.1002/imt2.213
Yaohua Wei, Feng Shen, Huidong Song, Ruifang Zhao, Weiyue Feng, Yue Pan, Xiaobo Li, Huanling Yu, Giuseppe Familiari, Michela Relucenti, Michael Aschner, Hanping Shi, Rui Chen, Guangjun Nie, Hanqing Chen
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Abstract

The gut microbiota is an integral component of the colorectal cancer (CRC) microenvironment and is intimately associated with CRC initiation, progression, and therapeutic outcomes. We reviewed recent advancements in utilizing nanotechnology for modulating gut microbiota, discussing strategies and the mechanisms underlying their design. For future nanomedicine design, we propose a 5I principle for individualized nanomedicine in CRC management.

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肠道微生物群靶向纳米药物治疗结直肠癌的挑战与机遇
肠道微生物群是结直肠癌(CRC)微环境不可或缺的组成部分,与 CRC 的发生、发展和治疗效果密切相关。我们回顾了利用纳米技术调节肠道微生物群的最新进展,讨论了相关策略及其设计机制。对于未来的纳米药物设计,我们提出了治疗 CRC 的个性化纳米药物 5I 原则。
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