A Highly Sensitive Plasmonic Graphene-Based Structure for Deoxyribonucleic Acid Detection

IF 4.7 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-06-09 DOI:10.3390/photonics11060549
Z. Salehnezhad, M. Soroosh, Haraprasad Mondal
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Abstract

In this study, a Kretschmann structure with a hybrid layer of graphene–WS2 is designed to develop a sensitive biosensor for deoxyribonucleic acid detection. The biosensor incorporates a 45 nm gold layer as the active layer and a thin film of chrome as the adhesive layer. Through the optimization of the graphene and WS2 layers, combined with the implementation of a silicon layer, we can enhance the nano-sensor’s sensitivity. The thin silicon layer acts as a protective barrier for the metal, while also increasing the volume of interaction. Consequently, by adjusting the thickness of the active metal and adding a silicon layer, we achieve higher sensitivity and a lower full width at half maximum, leading to sensitivity of 333.33°/RIU. The designed structure is analyzed using numerical techniques and the finite difference time domain method, allowing us to obtain the optical characteristics of the surface plasmon polariton sensor. Various parameters are calculated and evaluated to determine the optimal conditions for the sensor. Furthermore, the total size of the sensor is 2.228 µm2.
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用于脱氧核糖核酸检测的高灵敏度石墨烯基等离子结构
本研究设计了一种具有石墨烯-WS2 混合层的 Kretschmann 结构,用于开发一种灵敏的脱氧核糖核酸检测生物传感器。该生物传感器以 45 纳米的金层作为活性层,以铬薄膜作为粘合层。通过优化石墨烯层和 WS2 层,再加上硅层,我们可以提高纳米传感器的灵敏度。薄薄的硅层既是金属的保护屏障,又增加了相互作用的体积。因此,通过调整活性金属的厚度和添加硅层,我们可以获得更高的灵敏度和更低的半最大全宽,从而使灵敏度达到 333.33°/RIU。利用数值技术和有限差分时域法分析了所设计的结构,从而获得了表面等离子体极化子传感器的光学特性。通过计算和评估各种参数,确定了传感器的最佳条件。此外,传感器的总尺寸为 2.228 µm2。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
期刊介绍: ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.
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