Trisodium citrate dihydrate catalyzed one-pot four component synthesis of spiropyrano-indenoquinoxaline derivatives and their molecular docking analysis on the anti-cancer efficacies

Abstract

A efficient, simple and facile protocol has been developed for the synthesis of a series of spiropyrano-indenoquinoxaline derivatives via one-pot four component reactions of ninhydrin, o -phenylenediamines, malononitrile and various C-H activated acids using a catalytic amount of trisodium citrate dihydrate as catalyst in an aqueous ethanol under refluxed conditions. The docking analysis revealed promising anti-cancer activities of these synthesized compounds.