Platelets in Thrombosis and Atherosclerosis

IF 4.7 2区 医学 Q1 PATHOLOGY American Journal of Pathology Pub Date : 2024-06-15 DOI:10.1016/j.ajpath.2024.05.010
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Abstract

This review focuses on the dual role of platelets in atherosclerosis and thrombosis, exploring their involvement in inflammation, angiogenesis, and plaque formation, as well as their hemostatic and prothrombotic functions. Beyond their thrombotic functions, platelets engage in complex interactions with diverse cell types, influencing disease resolution and progression. The contribution of platelet degranulation helps in the formation of atheromatous plaque, whereas the reciprocal interaction with monocytes adds complexity. Alterations in platelet membrane receptors and signaling cascades contribute to advanced atherosclerosis, culminating in atherothrombotic events. Understanding these multifaceted roles of platelets will lead to the development of targeted antiplatelet strategies for effective cardiovascular disease prevention and treatment. Understanding platelet functions in atherosclerosis and atherothrombosis at different stages of disease will be critical for designing targeted treatments and medications to prevent or cure the disease Through this understanding, platelets can be targeted at specific times in the atherosclerosis process, possibly preventing the development of atherothrombosis.

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血小板在血栓形成和动脉粥样硬化中的作用:一把双刃剑。
本综述侧重于血小板在动脉粥样硬化和血栓形成中的双重作用,探讨它们在炎症、血管生成和斑块形成中的参与,以及它们的止血和促血栓形成功能。除了血栓形成功能外,血小板还与不同类型的细胞发生复杂的相互作用,影响疾病的缓解和发展。血小板脱颗粒有助于动脉粥样斑块的形成,而与单核细胞的相互影响则增加了其复杂性。血小板膜受体和信号级联的改变会导致晚期动脉粥样硬化,最终引发动脉粥样硬化血栓事件。了解血小板的这些多方面作用将有助于开发有针对性的抗血小板策略,从而有效预防和治疗心血管疾病。了解血小板在动脉粥样硬化和动脉粥样硬化栓塞症不同阶段的功能,对于设计有针对性的治疗方法和药物来预防或治疗疾病至关重要。
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来源期刊
CiteScore
11.40
自引率
0.00%
发文量
178
审稿时长
30 days
期刊介绍: The American Journal of Pathology, official journal of the American Society for Investigative Pathology, published by Elsevier, Inc., seeks high-quality original research reports, reviews, and commentaries related to the molecular and cellular basis of disease. The editors will consider basic, translational, and clinical investigations that directly address mechanisms of pathogenesis or provide a foundation for future mechanistic inquiries. Examples of such foundational investigations include data mining, identification of biomarkers, molecular pathology, and discovery research. Foundational studies that incorporate deep learning and artificial intelligence are also welcome. High priority is given to studies of human disease and relevant experimental models using molecular, cellular, and organismal approaches.
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