Incidence and prevalence of primary biliary cholangitis in the Netherlands – A nationwide cohort study

IF 9.5 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY JHEP Reports Pub Date : 2024-06-06 DOI:10.1016/j.jhepr.2024.101132
{"title":"Incidence and prevalence of primary biliary cholangitis in the Netherlands – A nationwide cohort study","authors":"","doi":"10.1016/j.jhepr.2024.101132","DOIUrl":null,"url":null,"abstract":"<div><h3>Background &amp; Aims</h3><p>Although primary biliary cholangitis (PBC) is considered a rare disorder, accurate determination of its incidence and prevalence remains challenging due to limited comprehensive population-based registries. We aimed to assess the incidence and prevalence of PBC in the Netherlands over time through the nationwide Dutch PBC Cohort Study (DPCS).</p></div><div><h3>Methods</h3><p>DPCS retrospectively included every identifiable patient with PBC in the Netherlands from 1990 onwards in all 71 Dutch hospitals. Incidence and prevalence were assessed between 2008-2018 by Poisson regression between sex and age groups over time.</p></div><div><h3>Results</h3><p>On the 1<sup>st</sup> of January 2008, there were 1,458 patients with PBC in the Netherlands. Between 2008-2018, 2,187 individuals were newly diagnosed, 46 were transplanted and 468 died. The yearly incidence of PBC in 2008 was 1.38, increasing to 1.74 per 100,000 persons in 2018. When compared to those aged &lt;45 years, females aged 45-64 years (adjusted incidence rate ratio 4.21, 95% CI 3.76-4.71, <em>p</em> &lt;0.001) and males ≥65 years (adjusted incidence rate ratio 14.41, 95% CI 9.62-21.60, <em>p</em> &lt;0.001) were at the highest risk of being diagnosed with PBC. The male-to-female ratio of patients newly diagnosed with PBC during the study period was 1:14 in those &lt;45 years, 1:10 in patients aged 45-64 years, and 1:4 in those ≥65 years. Point prevalence increased from 11.9 in 2008 to 21.5 per 100,000 persons in 2018. Average annual percent change in this time period was 5.94% (95% CI 5.77-6.15, <em>p</em> &lt;0.05), and was the highest among the population aged ≥65 years (5.69%, 95% CI 5.32-6.36, <em>p</em> &lt;0.001).</p></div><div><h3>Conclusions</h3><p>In this nationwide cohort study, we observed an increase in both the incidence and prevalence of PBC in the Netherlands over the past decade, with marked age and sex differences.</p></div><div><h3>Impact and implications:</h3><p>This nationwide Dutch primary biliary cholangitis (PBC) Cohort Study, including all hospitals in the Netherlands, showed that the incidence and prevalence of PBC have increased over the last decade. The age-dependent PBC incidence rate differed for males (highest risk ≥65 years) and females (highest risk between 45 and 65 years), which may be related to a difference in the timing of exposure to environmental triggers of PBC. The largest increase in PBC prevalence over time was observed in the population aged ≥65 years, which may have implications for the use of second-line therapies. These results therefore indicate that further studies are needed to elaborate on the advantages and disadvantages of add-on therapies in the elderly population.</p></div>","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"6 8","pages":"Article 101132"},"PeriodicalIF":9.5000,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589555924001368/pdfft?md5=36ae593715bf3a8e6eab6b40e1835d58&pid=1-s2.0-S2589555924001368-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"JHEP Reports","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2589555924001368","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background & Aims

Although primary biliary cholangitis (PBC) is considered a rare disorder, accurate determination of its incidence and prevalence remains challenging due to limited comprehensive population-based registries. We aimed to assess the incidence and prevalence of PBC in the Netherlands over time through the nationwide Dutch PBC Cohort Study (DPCS).

Methods

DPCS retrospectively included every identifiable patient with PBC in the Netherlands from 1990 onwards in all 71 Dutch hospitals. Incidence and prevalence were assessed between 2008-2018 by Poisson regression between sex and age groups over time.

Results

On the 1st of January 2008, there were 1,458 patients with PBC in the Netherlands. Between 2008-2018, 2,187 individuals were newly diagnosed, 46 were transplanted and 468 died. The yearly incidence of PBC in 2008 was 1.38, increasing to 1.74 per 100,000 persons in 2018. When compared to those aged <45 years, females aged 45-64 years (adjusted incidence rate ratio 4.21, 95% CI 3.76-4.71, p <0.001) and males ≥65 years (adjusted incidence rate ratio 14.41, 95% CI 9.62-21.60, p <0.001) were at the highest risk of being diagnosed with PBC. The male-to-female ratio of patients newly diagnosed with PBC during the study period was 1:14 in those <45 years, 1:10 in patients aged 45-64 years, and 1:4 in those ≥65 years. Point prevalence increased from 11.9 in 2008 to 21.5 per 100,000 persons in 2018. Average annual percent change in this time period was 5.94% (95% CI 5.77-6.15, p <0.05), and was the highest among the population aged ≥65 years (5.69%, 95% CI 5.32-6.36, p <0.001).

Conclusions

In this nationwide cohort study, we observed an increase in both the incidence and prevalence of PBC in the Netherlands over the past decade, with marked age and sex differences.

Impact and implications:

This nationwide Dutch primary biliary cholangitis (PBC) Cohort Study, including all hospitals in the Netherlands, showed that the incidence and prevalence of PBC have increased over the last decade. The age-dependent PBC incidence rate differed for males (highest risk ≥65 years) and females (highest risk between 45 and 65 years), which may be related to a difference in the timing of exposure to environmental triggers of PBC. The largest increase in PBC prevalence over time was observed in the population aged ≥65 years, which may have implications for the use of second-line therapies. These results therefore indicate that further studies are needed to elaborate on the advantages and disadvantages of add-on therapies in the elderly population.

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
荷兰原发性胆汁性胆管炎的发病率和流行率 - 一项全国性队列研究
背景& 目的虽然原发性胆汁性胆管炎(PBC)被认为是一种罕见疾病,但由于基于人群的综合登记有限,准确确定其发病率和流行率仍具有挑战性。我们旨在通过全国性的荷兰原发性胆汁性胆管炎队列研究(DPCS)评估荷兰历年来原发性胆汁性胆管炎的发病率和流行率。结果 2008年1月1日,荷兰共有1458名PBC患者。2008-2018 年间,2187 人新确诊,46 人接受移植,468 人死亡。2008 年,PBC 的年发病率为 1.38,2018 年增至每 10 万人 1.74。与 45 岁人群相比,45-64 岁女性(调整后发病率比为 4.21,95% CI 为 3.76-4.71,p<0.001)和≥65 岁男性(调整后发病率比为 14.41,95% CI 为 9.62-21.60,p<0.001)被诊断为 PBC 的风险最高。研究期间新诊断为 PBC 的患者中,45 岁患者的男女比例为 1:14,45-64 岁患者的男女比例为 1:10,≥65 岁患者的男女比例为 1:4。点患病率从 2008 年的每 10 万人 11.9 例上升到 2018 年的 21.5 例。这一时期的年均百分比变化率为 5.94%(95% CI 5.77-6.15,p <0.05),在年龄≥65 岁的人群中最高(5.69%,95% CI 5.32-6.36,p <0.001)。结论在这项全国范围的队列研究中,我们观察到荷兰 PBC 的发病率和患病率在过去十年中均有所上升,且存在明显的年龄和性别差异。影响和意义:这项全国性的荷兰原发性胆汁性胆管炎(PBC)队列研究包括荷兰的所有医院,研究结果表明,在过去十年中,PBC的发病率和患病率均有所上升。男性(≥65 岁风险最高)和女性(45 岁至 65 岁风险最高)的 PBC 发病率与年龄有关,这可能与接触 PBC 环境诱因的时间不同有关。随着时间的推移,在年龄≥65 岁的人群中观察到的 PBC 患病率增幅最大,这可能会对二线疗法的使用产生影响。因此,这些结果表明,还需要进一步的研究来阐述附加疗法在老年人群中的利弊。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
JHEP Reports
JHEP Reports GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
12.40
自引率
2.40%
发文量
161
审稿时长
36 days
期刊介绍: JHEP Reports is an open access journal that is affiliated with the European Association for the Study of the Liver (EASL). It serves as a companion journal to the highly respected Journal of Hepatology. The primary objective of JHEP Reports is to publish original papers and reviews that contribute to the advancement of knowledge in the field of liver diseases. The journal covers a wide range of topics, including basic, translational, and clinical research. It also focuses on global issues in hepatology, with particular emphasis on areas such as clinical trials, novel diagnostics, precision medicine and therapeutics, cancer research, cellular and molecular studies, artificial intelligence, microbiome research, epidemiology, and cutting-edge technologies. In summary, JHEP Reports is dedicated to promoting scientific discoveries and innovations in liver diseases through the publication of high-quality research papers and reviews covering various aspects of hepatology.
期刊最新文献
Contents Editorial Board page Copyright and information Contents ALT levels, alcohol use, and metabolic risk factors have prognostic relevance for liver-related outcomes in the general population
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1