A tale of two functions: C-reactive protein complement-ary structures and their role in rheumatoid arthritis

IF 4.5 3区 医学 Q2 IMMUNOLOGY Clinical immunology Pub Date : 2024-06-15 DOI:10.1016/j.clim.2024.110281
Coziana Ciurtin , Ghada Adly Helmy , Alexia Correia Ferreira , Jessica J. Manson , Elizabeth C. Jury , Thomas McDonnell
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Abstract

C-reactive protein (CRP) is an inflammatory biomarker with associated clinical utility in a wide number of inflammatory disorders, including rheumatoid arthritis (RA). The interaction of CRP with pro-inflammatory cytokines has been explored before, however its role in complement regulation is more subtle, where CRP is capable of both up and downregulating the complement cascade. CRP is produced in a pentameric form and can dissociate to a monomeric form in circulation which has significant implications for its ability to interact with receptors and binding partners. This dichotomy of CRP structure could have relevance in patients with RA who have significant dysfunction in their complement cascade and also widely varying CRP levels including at the time of flare. This review aims to bring together current knowledge of CRP in its various forms, its effects on complement function and how this could influence pathology in the context of RA.

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两种功能的故事:C 反应蛋白的补体结构及其在类风湿性关节炎中的作用
C反应蛋白(CRP)是一种炎症生物标志物,在包括类风湿性关节炎(RA)在内的多种炎症性疾病中具有相关的临床用途。CRP 与促炎细胞因子之间的相互作用已被研究过,但它在补体调节中的作用更为微妙,CRP 既能上调补体级联,也能下调补体级联。CRP 以五聚体形式产生,在血液循环中可解离为单体形式,这对其与受体和结合伙伴相互作用的能力有重大影响。CRP结构的这种二分法可能与RA患者有关,RA患者的补体级联功能严重失调,CRP水平差异很大,包括在病情发作时。本综述旨在汇集目前关于各种形式的CRP、其对补体功能的影响以及如何影响RA病理的知识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Clinical immunology
Clinical immunology 医学-免疫学
CiteScore
12.30
自引率
1.20%
发文量
212
审稿时长
34 days
期刊介绍: Clinical Immunology publishes original research delving into the molecular and cellular foundations of immunological diseases. Additionally, the journal includes reviews covering timely subjects in basic immunology, along with case reports and letters to the editor.
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