GPR30 is a potential player between islet cells and ductal HCO3− secretion

IF 4.3 2区 生物学 Q2 CELL BIOLOGY Cell calcium Pub Date : 2024-06-13 DOI:10.1016/j.ceca.2024.102922
Viktória Venglovecz , Péter Hegyi
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Abstract

The primary role of pancreatic ductal HCO3 secretion is to prevent premature activation of digestive enzymes and to provide a vehicle for the delivery of enzymes to the duodenum. In addition, HCO3is responsible for the neutralization of gastric juice and protect against the formation of protein plugs and viscous mucus. Due to this multifaceted role of HCO3 in the pancreas, its altered functioning can greatly contribute to the development of various exocrine diseases. It is well known that the exocrine and endocrine pancreas interact lively with each other, but not all details of this relationship are known. An interesting finding of a recent study by Jo-Watanabe et al. is that the G protein-coupled oestrogen receptor, GPR30, which is expressed in the endocrine pancreas, can be also activated by HCO3. This raises the possibility that ductal cells play a key role not only in the exocrine pancreas, but presumably also in endocrine function through HCO3 secretion.

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gpr30 是胰岛细胞与导管 hco3- 分泌之间的潜在参与者
胰腺导管分泌 HCO3- 的主要作用是防止消化酶过早活化,并为向十二指肠输送酶提供载体。此外,HCO3- 还负责中和胃液,防止形成蛋白栓和粘稠粘液。由于 HCO3- 在胰腺中的这种多方面作用,其功能的改变可在很大程度上导致各种外分泌疾病的发生。众所周知,胰腺外分泌和胰腺内分泌之间存在着活跃的互动关系,但这种关系的所有细节并不为人所知。Jo-Watanabe 等人最近的一项有趣研究发现,在胰腺内分泌系统中表达的 G 蛋白偶联雌激素受体 GPR30 也能被 HCO3- 激活。这就提出了一种可能性,即导管细胞不仅在胰腺外分泌中发挥关键作用,而且可能还通过分泌 HCO3- 在内分泌功能中发挥关键作用。
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来源期刊
Cell calcium
Cell calcium 生物-细胞生物学
CiteScore
8.70
自引率
5.00%
发文量
115
审稿时长
35 days
期刊介绍: Cell Calcium covers the field of calcium metabolism and signalling in living systems, from aspects including inorganic chemistry, physiology, molecular biology and pathology. Topic themes include: Roles of calcium in regulating cellular events such as apoptosis, necrosis and organelle remodelling Influence of calcium regulation in affecting health and disease outcomes
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