Concise synthetic routes for diphenylacetylene from tetrachloroethylene using Suzuki coupling reaction followed by treatment with n-butyllithium

IF 17.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-06-01 DOI:10.1093/chemle/upae043

Yuta Fujiki, Hiyono Suzuki, Junya Kikuzawa, Keiji Nishiwaki, N. Kawashita, Junpei Matsuoka, Akira Nakamura, Tomohiro Maegawa, Akiko Kuwabara, Masafumi Kobayashi, Kouichi Matsumoto

引用次数: 0

Abstract

We wish to report a new synthetic approach for diphenylacetylene in which tetrachloroethylene was reacted with phenylboronic acid in the presence of Pd catalyst, followed by a workup procedure to provide the crude product, which was then allowed to react with n-butyllithium via the halogen lithium exchange of Cl atom and loss of Li and Cl atoms to afford the desired diphenylacetylene in good yield.

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利用铃木偶联反应并用正丁基锂处理从四氯乙烯制备二苯基乙炔的简明合成路线

我们希望报告一种新的二苯基乙炔合成方法：在 Pd 催化剂存在下，四氯乙烯与苯硼酸发生反应，然后通过一个加工过程得到粗产物，再通过 Cl 原子的卤素锂交换以及 Li 原子和 Cl 原子的损失，使其与正丁基锂发生反应，从而以良好的收率得到所需的二苯基乙炔。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.