{"title":"Renamed, not tamed: angioimmunoblastic T-cell lymphoma, a diagnostic troublemaker","authors":"","doi":"10.1016/j.mpdhp.2024.05.007","DOIUrl":null,"url":null,"abstract":"<div><p>Angioimmunoblastic T-cell lymphoma was reclassified a subtype of nodal T-follicular helper cell lymphoma (nTFHL-AI) in the 5<sup>th</sup> Edition of the World Health Organization Classification of Haematolymphoid Tumours. It is now grouped with related entities upon recent discovery of a shared T-follicular helper (TFH) cell origin. Numerous studies attest to the many peculiar presentations that impede recognition of the disease. Surgical biopsy is often required to secure a diagnosis though is rarely the first-line intervention. Delayed or missed diagnosis has a high price. Advanced stage of disease at presentation is common and rates of relapse are high. There is an unmet need for earlier detection and improved outcomes. Here we present a case which showed some quintessential clinicopathologic features of nTFHL-AI, and an approach to discerning these is discussed.</p></div>","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"30 8","pages":"Pages 469-472"},"PeriodicalIF":0.0000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diagnostic Histopathology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1756231724000823","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Angioimmunoblastic T-cell lymphoma was reclassified a subtype of nodal T-follicular helper cell lymphoma (nTFHL-AI) in the 5th Edition of the World Health Organization Classification of Haematolymphoid Tumours. It is now grouped with related entities upon recent discovery of a shared T-follicular helper (TFH) cell origin. Numerous studies attest to the many peculiar presentations that impede recognition of the disease. Surgical biopsy is often required to secure a diagnosis though is rarely the first-line intervention. Delayed or missed diagnosis has a high price. Advanced stage of disease at presentation is common and rates of relapse are high. There is an unmet need for earlier detection and improved outcomes. Here we present a case which showed some quintessential clinicopathologic features of nTFHL-AI, and an approach to discerning these is discussed.
期刊介绍：
This monthly review journal aims to provide the practising diagnostic pathologist and trainee pathologist with up-to-date reviews on histopathology and cytology and related technical advances. Each issue contains invited articles on a variety of topics from experts in the field and includes a mini-symposium exploring one subject in greater depth. Articles consist of system-based, disease-based reviews and advances in technology. They update the readers on day-to-day diagnostic work and keep them informed of important new developments. An additional feature is the short section devoted to hypotheses; these have been refereed. There is also a correspondence section.
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