Yanju Song, Xin Luo, Liping Yao, YingChao Chen, Xinfa Mao
{"title":"A Novel Mechanism Linking Melatonin, Ferroptosis and Microglia Polarization via the Circodz3/HuR Axis in Subarachnoid Hemorrhage","authors":"Yanju Song, Xin Luo, Liping Yao, YingChao Chen, Xinfa Mao","doi":"10.1007/s11064-024-04193-x","DOIUrl":null,"url":null,"abstract":"<p>CircODZ3 is highly abundant in the plasma and cerebrospinal fluid from SAH patients.</p><p>Melatonin protects against SAH by inhibiting circodz3 expression.</p><p>Silencing of circodz3 inhibits ferroptosis and M1 polarization of BV2 microglia.</p><p>Circodz3 interacts with HuR to promote its ubiquitination and degradation.</p><p>Circodz3 degrades HuR to reduce SLC7A11 and GPX4 expression.</p>","PeriodicalId":719,"journal":{"name":"Neurochemical Research","volume":"49 9","pages":"2556 - 2572"},"PeriodicalIF":3.7000,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurochemical Research","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s11064-024-04193-x","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
CircODZ3 is highly abundant in the plasma and cerebrospinal fluid from SAH patients.
Melatonin protects against SAH by inhibiting circodz3 expression.
Silencing of circodz3 inhibits ferroptosis and M1 polarization of BV2 microglia.
Circodz3 interacts with HuR to promote its ubiquitination and degradation.
Circodz3 degrades HuR to reduce SLC7A11 and GPX4 expression.
期刊介绍：
Neurochemical Research is devoted to the rapid publication of studies that use neurochemical methodology in research on nervous system structure and function. The journal publishes original reports of experimental and clinical research results, perceptive reviews of significant problem areas in the neurosciences, brief comments of a methodological or interpretive nature, and research summaries conducted by leading scientists whose works are not readily available in English.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
